Provincial-Level Key Laboratory for Molecular Medicine of Major Diseases and The Prevention and Treatment with Traditional Chinese Medicine Research in Gansu Colleges and Universities, Gansu University of Chinese Medicine, Lanzhou, China.
Gansu Institute of Cardiovascular Diseases, The First People's Hospital of Lanzhou City, Lanzhou, China.
Front Immunol. 2022 Jan 5;12:810286. doi: 10.3389/fimmu.2021.810286. eCollection 2021.
The tumor microenvironment is essential for the formation and development of tumors. Cytokines in the microenvironment may affect the growth, metastasis and prognosis of tumors, and play different roles in different stages of tumors, of which transforming growth factor β (TGF-β) and tumor necrosis factor α (TNF-α) are critical. The two have synergistic and antagonistic effect on tumor regulation. The inhibition of TGF-β can promote the formation rate of tumor, while TGF-β can promote the malignancy of tumor. TNF-α was initially determined to be a natural immune serum mediator that can induce tumor hemorrhagic necrosis, it has a wide range of biological activities and can be used clinically as a target to immune diseases as well as tumors. However, there are few reports on the interaction between the two in the tumor microenvironment. This paper combs the biological effect of the two in different aspects of different tumors. We summarized the changes and clinical medication rules of the two in different tissue cells, hoping to provide a new idea for the clinical application of the two cytokines.
肿瘤微环境对于肿瘤的发生和发展至关重要。微环境中的细胞因子可能会影响肿瘤的生长、转移和预后，并在肿瘤的不同阶段发挥不同的作用，其中转化生长因子 β（TGF-β）和肿瘤坏死因子 α（TNF-α）至关重要。这两种细胞因子对肿瘤的调节具有协同和拮抗作用。抑制 TGF-β可以促进肿瘤的形成率，而 TGF-β 可以促进肿瘤的恶性程度。TNF-α最初被确定为一种天然免疫血清介质，可诱导肿瘤出血坏死，它具有广泛的生物学活性，可在临床上作为免疫疾病以及肿瘤的靶点。然而，关于两者在肿瘤微环境中的相互作用的报道较少。本文梳理了这两种细胞因子在不同肿瘤的不同方面的生物学效应。我们总结了这两种细胞因子在不同组织细胞中的变化及其临床用药规律，希望为这两种细胞因子的临床应用提供新的思路。
