Kotoku Naoyuki, Mizushima Kohei, Tamura Satoru, Kobayashi Motomasa
Graduate School of Pharmaceutical Sciences, Osaka University.
Chem Pharm Bull (Tokyo). 2013;61(10):1024-9. doi: 10.1248/cpb.c13-00375.
Syntheses of analogue compounds of cortistatin A (1), an anti-angiogenic steroidal alkaloid from Indonesian marine sponge, were investigated by utilizing the CD-ring fragment of vitamin D₂. The incidental preparation of a new analogue having CD-cis-fused skeleton and its biological evaluation revealed the importance of the CD-trans-fused structure for the potent and selective antiproliferative activity of 1 against human umbilical vein endothelial cells (HUVECs).
