The Key Laboratory of Synthetic Chemistry of Natural Substances and the State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
Org Lett. 2010 Nov 19;12(22):5135-7. doi: 10.1021/ol102058f. Epub 2010 Oct 6.
A concise synthetic approach for constructing the oxapentacyclic framework of cortistatin A is described. The synthesis features a furan-oxyallyl [4 + 3] cycloaddition and double-intramolecular aldol reactions. In addition, an interesting core structure was obtained in 11 steps from furan by using our method.
描述了一种构建考替他汀 A 的氧杂戊环骨架的简洁合成方法。该合成方法的特点是呋喃-氧烯丙基[4 + 3]环加成和双分子内羟醛缩合反应。此外，我们的方法还可以从呋喃出发经过 11 步反应得到有趣的核心结构。
