Seo Ji Ho, Lee Da Young, Hong Chang Woo, Lee In Hee, Ahn Ki Sung, Kang Gun Woo
Department of Internal Medicine, Catholic University of Daegu School of Medicine, Korea.
Intern Med. 2013;52(19):2245-8. doi: 10.2169/internalmedicine.52.0697. Epub 2012 Mar 1.
An 82-year-old woman with type 2 diabetes mellitus, hypertension, and unstable angina presented with severe lactic acidosis and acute kidney injury (AKI) accompanied by acute pancreatitis. Her medical history revealed that she had taken cimetidine for two weeks while taking other medications, including metformin. Continuous veno-venous hemodiafiltration (CVVHDF) was initiated under diagnosis of lactic acidosis due to metformin and AKI caused by cimetidine-induced acute pancreatitis. In three days of CVVHDF, the levels of serum biochemical markers of lactic acidosis and AKI improved and the patient's urine output reached over 1 L/day. The pancreatitis improved over time.
一名患有2型糖尿病、高血压和不稳定型心绞痛的82岁女性，出现严重乳酸酸中毒和急性肾损伤（AKI），并伴有急性胰腺炎。她的病史显示，在服用包括二甲双胍在内的其他药物期间，她服用西咪替丁两周。在诊断为二甲双胍引起的乳酸酸中毒和西咪替丁诱导的急性胰腺炎导致的AKI后，开始进行持续静脉-静脉血液透析滤过（CVVHDF）。在CVVHDF治疗的三天里，乳酸酸中毒和AKI的血清生化标志物水平有所改善，患者尿量达到每天1升以上。胰腺炎随着时间的推移有所改善。
