射频消融治疗中肝组织“热传导效应”的最佳条件。
Optimal conditions for "heat-conduct effect" in liver tissue during radiofrequency ablation.
机构信息
Institute and Hospital of Hepatobiliary Surgery Key Laboratory of Digital Hepatobiliary Surgery of Chinese PLA Chinese PLA Medical School Chinese PLA General Hospital, Beijing, China -
出版信息
Panminerva Med. 2013 Sep;55(3):297-302.
AIM
This study was conducted to optimize the "heat-conduct effect" to increase the efficacy of radiofrequency ablation (RFA) in the treatment of liver tumors.
METHODS
To simulate the "heat-conduct effect" caused by RFA, isolated pig livers were heated by an inserted metal tube through which water with different incoming temperatures was passed. The tissue temperature was measured within 5- and 10-mm radiuses. Further, changes in color and morphology of the tissue were recorded.
RESULTS
Using an incoming temperature of 70 °C, the effective ablation radius of 5 mm was achieved within 10 min. To expand the effective radius to 10 mm, the tube temperature needed to be maintained at above 80 °C for 40 min; alternatively, the tube temperature above 90 °C and heating time of 25 min were also sufficient.
CONCLUSION
To achieve the complete ablation in isolated liver within the 10 mm radius by "heat-conduct effect", the temperature of the heating center should be maintained above 80 - 90 °C with the exposure time of 25-40 min.
目的
本研究旨在优化“热传导效应”，以提高射频消融（RFA）治疗肝肿瘤的疗效。
方法
为了模拟 RFA 引起的“热传导效应”，通过插入的金属管将不同进水温度的水传递给离体猪肝，在 5-10mm 半径范围内测量组织温度。进一步记录组织颜色和形态的变化。
结果
采用 70°C 的进水温度，在 10 分钟内可达到 5mm 的有效消融半径。为了将有效半径扩大到 10mm，需要将管内温度保持在 80°C 以上 40 分钟；或者，管内温度高于 90°C 且加热时间为 25 分钟也足够。
结论
通过“热传导效应”，要在 10mm 半径内使离体肝脏完全消融，加热中心的温度应保持在 80-90°C 以上，暴露时间为 25-40 分钟。
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