Institute and Hospital of Hepatobiliary Surgery Key Laboratory of Digital Hepatobiliary Surgery of Chinese PLA Chinese PLA Medical School Chinese PLA General Hospital, Beijing, China -
Panminerva Med. 2013 Sep;55(3):297-302.
This study was conducted to optimize the "heat-conduct effect" to increase the efficacy of radiofrequency ablation (RFA) in the treatment of liver tumors.
To simulate the "heat-conduct effect" caused by RFA, isolated pig livers were heated by an inserted metal tube through which water with different incoming temperatures was passed. The tissue temperature was measured within 5- and 10-mm radiuses. Further, changes in color and morphology of the tissue were recorded.
Using an incoming temperature of 70 °C, the effective ablation radius of 5 mm was achieved within 10 min. To expand the effective radius to 10 mm, the tube temperature needed to be maintained at above 80 °C for 40 min; alternatively, the tube temperature above 90 °C and heating time of 25 min were also sufficient.
To achieve the complete ablation in isolated liver within the 10 mm radius by "heat-conduct effect", the temperature of the heating center should be maintained above 80 - 90 °C with the exposure time of 25-40 min.
本研究旨在优化“热传导效应”，以提高射频消融（RFA）治疗肝肿瘤的疗效。
为了模拟 RFA 引起的“热传导效应”，通过插入的金属管将不同进水温度的水传递给离体猪肝，在 5-10mm 半径范围内测量组织温度。进一步记录组织颜色和形态的变化。
采用 70°C 的进水温度，在 10 分钟内可达到 5mm 的有效消融半径。为了将有效半径扩大到 10mm，需要将管内温度保持在 80°C 以上 40 分钟；或者，管内温度高于 90°C 且加热时间为 25 分钟也足够。
通过“热传导效应”，要在 10mm 半径内使离体肝脏完全消融，加热中心的温度应保持在 80-90°C 以上，暴露时间为 25-40 分钟。
