Minami Masahiko, Takechi Masaaki, Ohta Kouji, Ohta Akira, Ninomiya Yoshiaki, Takamoto Megumi, Fukui Akiko, Tada Misato, Kamata Nobuyuki
Departments of Oral and Maxillofacial Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University.
Dent Mater J. 2013;32(5):753-60. doi: 10.4012/dmj.2012-169.
The aim of the present study was to examine whether interconnected porous hydroxyapatite ceramics (IP-CHA) could be used as bone substitute for implant treatment in reconstructive surgery. We firstly assessed if surround of the titanium surface placed into granular or block-type IP-CHA can observe new bone formation in a rabbit bone defect model. Subsequently, osseointegration and stability of titanium implant inserted into block-type IP-CHA was investigated in a rabbit onlay graft model. Direct contact between new bone and the surface of the titanium in granular- or block-type IP-CHA was found in a rabbit bone defect. Further, new bone formation was found in direct contact with the implant surface in the block-type IP-CHA in an onlay graft model, and the implant stability quotient (ISQ) values were significantly increased after surgery. Therefore, IP-CHA may be a useful material for implant treatment in reconstructive surgery strategies.
本研究的目的是检验相互连接的多孔羟基磷灰石陶瓷（IP-CHA）是否可用作骨替代物，用于重建手术中的植入治疗。我们首先评估了置于颗粒状或块状IP-CHA中的钛表面周围能否在兔骨缺损模型中观察到新骨形成。随后，在兔覆盖植骨模型中研究了插入块状IP-CHA的钛植入物的骨整合和稳定性。在兔骨缺损中发现新骨与颗粒状或块状IP-CHA中钛表面直接接触。此外，在覆盖植骨模型中，在块状IP-CHA中发现新骨与植入物表面直接接触，并且术后植入物稳定性商（ISQ）值显著增加。因此，IP-CHA可能是重建手术策略中植入治疗的有用材料。
