Edvardsson N, Hirsch I, Olsson S B
Eur Heart J. 1985 Jan;6(1):57-66. doi: 10.1093/oxfordjournals.eurheartj.a061755.
The acute electrophysiologic effects of clinical doses of procainamide, lidocaine, metoprolol, digoxin and atropine upon the conduction of ventricular premature beats, were studied in 48 healthy volunteers. The conduction time of the first premature beat, induced 1 ms after the ventricular effective refractory period (VERP) was longer than that of the basic paced beats in 41 of the 48 subjects (85%); in 31 (65%) the delay was greater than 5 ms, indicating subnormal conduction. Digoxin decreased the delay so that it became insignificant, while, after procainamide, the delay increased significantly. The other agents did not significantly affect the subnormal conduction. The mean conduction times of premature beats, induced 30-50 ms after the VERP, were shorter than the basic conduction time in 43 of the 48 subjects (90%), and in 25 (52%) the decrease was greater than 5 ms, showing supernormal conduction. Lidocaine abolished the supernormal conduction. The other agents did not significantly alter the supernormal conduction. In the healthy heart, sub- and supernormal conduction of premature beats seem to be common phenomena, and seem, with few exceptions, to be largely unaffected by clinical doses of procainamide, lidocaine, metoprolol, digoxin and atropine.
在48名健康志愿者中研究了临床剂量的普鲁卡因胺、利多卡因、美托洛尔、地高辛和阿托品对室性早搏传导的急性电生理效应。在48名受试者中的41名（85%）中，在心室有效不应期（VERP）后1毫秒诱发的第一个早搏的传导时间长于基本起搏搏动的传导时间；在31名（65%）中，延迟大于5毫秒，表明传导异常。地高辛减少了延迟，使其变得不显著，而在普鲁卡因胺之后，延迟显著增加。其他药物对传导异常没有显著影响。在VERP后30 - 50毫秒诱发的早搏的平均传导时间在48名受试者中的43名（90%）中短于基本传导时间，在25名（52%）中减少大于5毫秒，显示超常传导。利多卡因消除了超常传导。其他药物没有显著改变超常传导。在健康心脏中，早搏的亚正常和超常传导似乎是常见现象，并且似乎除了少数例外，在很大程度上不受临床剂量的普鲁卡因胺、利多卡因、美托洛尔、地高辛和阿托品的影响。
