McClendon Jamal, Smith Timothy R, Thompson Sara E, Sugrue Patrick A, Oʼshaughnessy Brian A, Ondra Stephen L, Koski Tyler R
*Department of Neurological Surgery, Northwestern Memorial Hospital, Chicago, Illinois; ‡Howell Allen Clinic, Nashville, Tennessee.
Neurosurgery. 2014 Jan;74(1):42-50; discussion 50. doi: 10.1227/NEU.0000000000000195.
Obesity is a dominant public health concern and risk factor for disability, with few studies examining its impact in spinal surgery. Patients with a higher body mass index (BMI) have lower functional status, increased pain, and worse physical condition than those with ideal weight.
To determine associations between BMI categories on adverse patient outcomes after long-segment spinal fusions.
Consecutive, open, elective fusions (interbody and/or posterolateral arthrodesis) of more than 5 levels from 2007 to 2010 were retrospectively analyzed with follow-up of more than 1 year. Bivariate analyses examined outcome variables based on BMI categories. Linear regression analysis evaluated BMI, hospital stay, and complications at 1 and 2 years, controlling for confounders. Mean and median follow-up lengths were 2.1 and 2.0 years, respectively.
A total of 189 surgeries on 112 patients, with a mean age of 59.5 years and a mean BMI of 29.8 kg/m, were analyzed. Morbidly obese patients had longer hospitalizations, worse Oswestry Disability Index (ODI), and more complications at 1 and 2 years than ideal weight patients. Multivariate linear regression modeling revealed sex, cardiac medications, cerebrospinal fluid leak, and BMI category of ideal vs nonideal influenced hospitalization length. Multivariate analysis showed BMI greater than 30 kg/m, preoperative ODI, and pedicle subtraction osteotomy influenced all complications at 1 year. Mean complications at 2 years for the morbidly obese were 3 times more than those underweight and 8 times more than those with ideal weight. Controlling for age, sex, and length of stay, obese and morbidly obese patients had more complications at 2 years; morbidly obese patients had a worse 2-year ODI.
BMI is an independent predictor of hospitalization length and all complications at 1 and 2 years in patients receiving long-segment fusions.
肥胖是一个主要的公共卫生问题和致残风险因素,很少有研究探讨其在脊柱手术中的影响。与体重理想的患者相比,体重指数(BMI)较高的患者功能状态较差、疼痛加剧且身体状况更糟。
确定长节段脊柱融合术后BMI类别与不良患者预后之间的关联。
对2007年至2010年连续进行的5个以上节段的开放性择期融合术(椎间融合和/或后外侧关节融合术)进行回顾性分析,随访时间超过1年。双变量分析根据BMI类别检查结局变量。线性回归分析评估BMI、住院时间以及1年和2年时的并发症情况,并对混杂因素进行控制。平均随访时间和中位随访时间分别为2.1年和2.0年。
共分析了112例患者的189例手术,患者平均年龄为59.5岁,平均BMI为29.8kg/m²。与体重理想的患者相比,病态肥胖患者住院时间更长、奥斯维斯特里功能障碍指数(ODI)更差,且在1年和2年时并发症更多。多变量线性回归模型显示,性别、心脏药物、脑脊液漏以及理想体重与非理想体重的BMI类别会影响住院时间。多变量分析显示,BMI大于30kg/m²、术前ODI以及椎弓根截骨术会影响1年时的所有并发症。病态肥胖患者2年时的平均并发症是体重过轻患者的3倍,是体重理想患者的8倍。在控制年龄、性别和住院时间后,肥胖和病态肥胖患者在2年时并发症更多;病态肥胖患者2年时的ODI更差。
BMI是接受长节段融合术患者住院时间以及1年和2年时所有并发症的独立预测因素。