From the *Diagnostic Center Diagnostiko Iatriki A.E., Larissa; and †Department of Nuclear Medicine, School of Medicine, University of Patras, Patras, Greece.
Clin Nucl Med. 2013 Nov;38(11):910-2. doi: 10.1097/RLU.0b013e3182a75940.
Recent case series have identified the presence of atypical insufficiency fractures at the diaphyseal femur of osteoporotic patients, which are possibly related to the long-term use of biphosphonates. We present images of a 72-year-old woman with a history of colon cancer and osteoporosis referred for bone scintigraphy because of bilateral thigh pain. No trauma or intense exercise was reported. Bone scan revealed bilateral femoral shaft stress fractures, which were confirmed by plain radiographs. In oncologic patients with osteoporosis referred for bone scintigraphy, atypical stress fractures should be included in the differential diagnosis of focal findings in the diaphyseal femur.
最近的病例系列研究发现，骨质疏松症患者骨干股骨存在非典型的不稳定性骨折，这可能与长期使用双膦酸盐有关。我们呈现了一位 72 岁女性的图像，她患有结肠癌和骨质疏松症，因双侧大腿疼痛而接受骨闪烁扫描检查。据报告，她没有受到创伤或剧烈运动。骨扫描显示双侧股骨干应力性骨折，平片证实了这一点。对于因骨质疏松症而接受骨闪烁扫描检查的肿瘤患者，在骨干股骨局灶性表现的鉴别诊断中应包括非典型性应力性骨折。
