Brückner R, Gramann S, Nose M, Schmitz W, Scholz H
Experientia. 1985 Jun 15;41(6):732-4. doi: 10.1007/BF02012570.
The phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (IBMX) mimicked the effects of isoprenaline on the force of contraction, the cAMP content and the slow Ca++ inward current (Isi) in isolated guinea pig papillary muscles. The results support the hypothesis that phosphodiesterase inhibitors and beta-adrenoceptor agonists exert their positive inotropic effects by increasing Isi via the common mediator cAMP.
磷酸二酯酶抑制剂3-异丁基-1-甲基黄嘌呤（IBMX）模拟了异丙肾上腺素对豚鼠离体乳头肌收缩力、环磷酸腺苷（cAMP）含量及慢钙内流电流（Isi）的作用。这些结果支持了以下假说：磷酸二酯酶抑制剂和β-肾上腺素能受体激动剂通过共同的介质环磷酸腺苷增加慢钙内流电流，从而发挥其正性肌力作用。
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