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The effects of beta-sympathomimetic amines and phosphodiesterase inhibitors on electrophysiological parameters in Purkinje fibres.

作者信息

Schulze J J, Averesch H

出版信息

Experientia. 1980 May 15;36(5):588-90. doi: 10.1007/BF01965819.

DOI:10.1007/BF01965819
PMID:6155287
Abstract

Dose-dependent responses to L-isoprenaline of spontaneous activity and plateau height in Purkinje fibres can be mimicked closely by the PDE-inhibitor IBMX. Simultaneous applications of sympathomimetic amines and IBMX result in potentiated responses. The results support the hypothesis that cyclic-AMP is the common mediator of positive chronotropic and inotropic effects induced by beta-sympathomimetic amines.

摘要

相似文献

1
The effects of beta-sympathomimetic amines and phosphodiesterase inhibitors on electrophysiological parameters in Purkinje fibres.
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2
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本文引用的文献

1
Effects of epinephrine on the pacemaker potassium current of cardiac Purkinje fibers.肾上腺素对心脏浦肯野纤维起搏钾电流的影响。
J Gen Physiol. 1974 Sep;64(3):293-319. doi: 10.1085/jgp.64.3.293.
2
Localization of beta adrenergic receptors, and effects of noradrenaline and cyclic nucleotides on action potentials, ionic currents and tension in mammalian cardiac muscle.β-肾上腺素能受体的定位，以及去甲肾上腺素和环核苷酸对哺乳动物心肌动作电位、离子电流和张力的影响。
J Physiol. 1974 Oct;242(2):429-51. doi: 10.1113/jphysiol.1974.sp010716.
3
Effects of several phosphodiesterase-inhibitors on guinea-pig myocardium.
Naunyn Schmiedebergs Arch Pharmacol. 1978 Mar;302(1):77-86. doi: 10.1007/BF00586601.
4
The effects of isoprenaline and a new beta-sympathomimetic amine upon spontaneous activity, diastolic depolarization and plateau height in cardiac Purkinje fibres.异丙肾上腺素和一种新型β-拟交感胺对心脏浦肯野纤维自发活动、舒张期去极化及平台期高度的影响。
Br J Pharmacol. 1978 Jul;63(3):427-34. doi: 10.1111/j.1476-5381.1978.tb07794.x.