Varga G, Scarpignato C, Papp M
Digestion. 1985;31(4):177-82. doi: 10.1159/000199196.
The effect of ranitidine (20 mg . kg-1) and cimetidine (50 mg . kg-1) on pancreatic secretory and trophic responses to caerulein (1 microgram . kg-1) was studied in the rat. Ranitidine or cimetidine were administered alone or combined with caerulein twice a day for 7 days. Saline-treated rats were used as controls. At the end of treatment animals were anesthetized and pancreatic juice was collected for 1 h after intravenous secretin plus CCK-PZ (8 U . kg-1). Afterwards rats were sacrificed and growth and composition of pancreatic tissue were determined. Compared with control (saline) values, volume of pancreatic juice and output of trypsin and amylase were increased by treatment with caerulein. Ranitidine, when given combined with caerulein, completely abolished the secretory response induced by the peptide, whereas it was totally ineffective when given alone. Cimetidine (alone or combined with caerulein) was always ineffective. Caerulein increased pancreatic weight, total pancreatic trypsin, amylase and RNA content. Here again ranitidine, combined with caerulein, abolished almost completely the trophic effect of caerulein on the pancreas, but when given alone it did not influence pancreatic growth and composition. Also in this case, cimetidine was completely inactive. These results suggest that ranitidine affects exocrine pancreas with an action independent of the H2-receptor blockade.
研究了雷尼替丁（20毫克·千克⁻¹）和西咪替丁（50毫克·千克⁻¹）对大鼠胰腺对蛙皮素（1微克·千克⁻¹）分泌和营养反应的影响。雷尼替丁或西咪替丁单独给药或与蛙皮素联合给药，每天两次，共7天。用生理盐水处理的大鼠作为对照。治疗结束时，将动物麻醉，在静脉注射促胰液素加胆囊收缩素-胰酶泌素（8单位·千克⁻¹）后收集1小时的胰液。之后处死大鼠，测定胰腺组织的生长和组成。与对照（生理盐水）值相比，蛙皮素治疗可增加胰液体积以及胰蛋白酶和淀粉酶的分泌量。雷尼替丁与蛙皮素联合给药时，可完全消除该肽诱导的分泌反应，而单独给药时则完全无效。西咪替丁（单独或与蛙皮素联合）始终无效。蛙皮素可增加胰腺重量、胰腺总胰蛋白酶、淀粉酶和RNA含量。同样，雷尼替丁与蛙皮素联合使用时，几乎完全消除了蛙皮素对胰腺的营养作用，但单独给药时不影响胰腺生长和组成。在这种情况下，西咪替丁也完全无活性。这些结果表明，雷尼替丁对胰腺外分泌的作用与其对H2受体的阻断作用无关。
