Mansi C, Mela G S, Sciabà L, Pasini D, Chiaramondia M, Celle G
Instituto Scientifico di Medicina Interna, Università di Genova, Italia.
Digestion. 1988;41(3):129-35. doi: 10.1159/000199764.
This study deals with the effect of H2-receptor antagonists on pancreatic response to chronic administration of caerulein. Caerulein was administered alone or combined with cimetidine, ranitidine or famotidine twice a day in various regimes. At the end of treatment, pure pancreatic juice was collected after hormonal stimulation. Then, the rats were killed, and growth and composition of the pancreatic tissue were determined. Caerulein increased pancreatic weight and enzyme content as well as volume and enzyme activity of pancreatic juice. When given alone the three H2-receptor antagonists were totally ineffective. Both ranitidine and famotidine, but not cimetidine, significantly reduced pancreatic response to chronic administration of caerulein only when given intraperitoneally together with caerulein. On the contrary, separate applications of caerulein and ranitidine (or famotidine) did not influence caerulein-stimulated pancreatic growth or enzyme secretion. Moreover, in rats treated both intraperitoneally and subcutaneously with caerulein, the H2-antagonists reduced the pancreatic response only partially and in proportion to the intraperitoneal dose of caerulein. The responsiveness of pancreatic tissue to subcutaneous caerulein was not modified. The results suggest that H2-receptor antagonists induce (1) impaired uptake of caerulein when given together with peptide, but (2) have no specific inhibitory effect on pancreatic response to caerulein.
本研究探讨了H2受体拮抗剂对胰腺对长期注射蛙皮素反应的影响。蛙皮素单独给药或与西咪替丁、雷尼替丁或法莫替丁以不同方案每日给药两次。治疗结束时，经激素刺激后收集纯胰液。然后处死大鼠，测定胰腺组织的生长和组成。蛙皮素增加了胰腺重量、酶含量以及胰液的体积和酶活性。单独给予时，三种H2受体拮抗剂完全无效。仅当雷尼替丁和法莫替丁与蛙皮素腹腔内联合给药时，可显著降低胰腺对长期注射蛙皮素的反应，而西咪替丁则无此作用。相反，分别应用蛙皮素和雷尼替丁（或法莫替丁）并不影响蛙皮素刺激的胰腺生长或酶分泌。此外，在经腹腔和皮下注射蛙皮素治疗的大鼠中，H2拮抗剂仅部分降低胰腺反应，且与蛙皮素的腹腔内剂量成比例。胰腺组织对皮下注射蛙皮素的反应性未发生改变。结果表明，H2受体拮抗剂（1）与肽一起给药时会导致蛙皮素摄取受损，但（2）对胰腺对蛙皮素的反应无特异性抑制作用。
