Yale Dermatologic Surgery, Yale University, New Haven, Connecticut.
Dermatol Surg. 2013 Oct;39(10):1507-13. doi: 10.1111/dsu.12315.
The risk of skin cancer in solid organ transplant recipients (SOTR) is 50 to 100 times as great as in those without a transplant. Multiple factors, including immunosuppression, influence the development of post-transplantation skin cancer. Individuals with cardiac transplant are serially screened for organ rejection and immunosuppressive regimen effectiveness. Gene expression profiling of peripheral blood mononuclear cells has been established as a noninvasive test for monitoring cardiac rejection.
We examined individuals with cardiac transplant monitored using peripheral gene expression profiling to determine whether the profile of peripheral blood mononuclear cell activity could correlate with the development of post-transplantation skin cancer.
Sixty-one patient records were examined for initial endomyocardial biopsy results, gene expression profiling data, immunosuppressive regimens, and post-transplantation skin cancer.
There was no relationship between acute rejection and the development of skin cancer. No relationship between peripheral gene expression profiling and the development of post-transplantation skin cancer was observed. The most common skin cancer in the population was squamous cell carcinoma. SOTR suppressed with azathioprine had a significantly higher incidence of squamous cell carcinoma.
Although gene expression tests have advanced transplant surveillance, they were not associated with post-transplantation skin cancer.
实体器官移植受者（SOTR）患皮肤癌的风险比未接受移植的人高 50 到 100 倍。多种因素，包括免疫抑制，影响移植后皮肤癌的发展。心脏移植患者会进行器官排斥和免疫抑制方案有效性的连续筛查。外周血单个核细胞的基因表达谱已被确立为监测心脏排斥的非侵入性测试。
我们检查了使用外周基因表达谱监测的心脏移植个体，以确定外周血单个核细胞活性的特征是否与移植后皮肤癌的发展相关。
检查了 61 例患者的记录，包括初始心内膜心肌活检结果、基因表达谱数据、免疫抑制方案和移植后皮肤癌。
急性排斥与皮肤癌的发生之间没有关系。未观察到外周基因表达谱与移植后皮肤癌的发生之间存在关系。该人群中最常见的皮肤癌是鳞状细胞癌。接受硫唑嘌呤抑制的 SOTR 鳞状细胞癌的发病率显著更高。
尽管基因表达测试已经推进了移植监测，但它们与移植后皮肤癌无关。
