University of Zagreb School of Medicine, Zagreb, Croatia.
Department of Dermatovenereology, Zagreb University Hospital Center, Zagreb, Croatia.
Acta Clin Croat. 2022 Mar;61(1):157-165. doi: 10.20471/acc.2022.61.01.21.
Nonmelanoma skin cancers (NMSC) are the most common malignancies in solid organ transplant recipients. The most common types of skin cancer in these patients are squamous cell carcinoma (SCC), followed by basal cell carcinoma. In immunosuppressed patients, specifically patients after solid organ transplantation, these carcinomas tend to be more aggressive and have a much higher incidence of metastasizing compared to general population. We present a case of a patient who developed numerous SCCs after successful heart transplantation. SCCs which occurred in our patient were mostly treated surgically. However, the lesion on the scalp relapsed after it had been treated surgically three times and therefore superficial x-ray radiation therapy was administered due to its localization and extensive size. In the next year, five more new SCCs occurred throughout the patient's body and all of them were removed surgically. Soon afterwards, the patient died from adenocarcinoma of the colon which rapidly progressed and metastasized.
非黑色素瘤皮肤癌(NMSC)是实体器官移植受者中最常见的恶性肿瘤。这些患者中最常见的皮肤癌类型是鳞状细胞癌(SCC),其次是基底细胞癌。在免疫抑制患者中,特别是实体器官移植后的患者,与一般人群相比,这些癌往往更具侵袭性,转移的发生率更高。我们报告了 1 例成功心脏移植后发生多处 SCC 的患者。我们患者的 SCC 主要通过手术治疗。然而,头皮上的病变在经过 3 次手术治疗后复发,因此由于其位置和广泛的大小,给予浅层 X 射线放射治疗。在接下来的 1 年中,患者全身又出现了 5 个新的 SCC,均通过手术切除。此后不久,患者死于迅速进展和转移的结肠癌腺癌。