Ungari S, Katari R S, Alessandri G, Gullino P M
Invasion Metastasis. 1985;5(4):193-205.
Angiogenesis is indispensable to sustain promotion and growth of metastases. As a contribution to the understanding of the angiogenesis process, the experiments reported showed that: (a) fibronectin is involved in the mobilization of capillary endothelium which is the first event in angiogenesis; (b) antifibronectin serum can block the mobilization, and neutralization of the antiserum can restore it; (c) the combination of fibronectin + heparin is a powerful mobilizer of capillary endothelium, and (d) fragments of the fibronectin and heparin molecules in combination can mobilize capillary endothelium as effectively as the intact molecules. The results are interpreted to indicate that molecules normally present in the extracellular matrix like heparin and fibronectin, may act as angiogenesis effectors when the physiological structure of the tissue is altered, for instance by lytic enzymes released by metastatic neoplastic cells.
血管生成对于维持转移灶的进展和生长必不可少。作为对血管生成过程理解的一项贡献，所报道的实验表明：(a) 纤连蛋白参与毛细血管内皮细胞的动员，这是血管生成的首个事件；(b) 抗纤连蛋白血清可阻断该动员过程，而抗血清的中和作用可使其恢复；(c) 纤连蛋白 + 肝素的组合是毛细血管内皮细胞的强力动员剂，并且 (d) 纤连蛋白和肝素分子的片段组合可与完整分子一样有效地动员毛细血管内皮细胞。这些结果被解释为表明，诸如肝素和纤连蛋白等通常存在于细胞外基质中的分子，在组织的生理结构发生改变时，例如被转移性肿瘤细胞释放的溶解酶改变时，可能充当血管生成效应物。
