Angiogenesis in vivo and selective mobilization of capillary endothelium in vitro by heparin-copper complex.

The objective of this work was to contribute to the interpretation of the mechanisms of capillary formation in the adult tissues. We have observed that the heparin-copper complex is angiogenic in vivo and stimulates migration of capillary endothelium in vitro. This effect is specific for capillary endothelium since aortic endothelium or fibroblasts from the rabbit cornea or human skin were unresponsive.