临床前阿尔茨海默病老年人异常 P600 单词重复效应。
Abnormal P600 word repetition effect in elderly persons with preclinical Alzheimer's disease.
机构信息
a Department of Neurology , University of California , Davis , CA , USA.
出版信息
Cogn Neurosci. 2013;4(3-4):143-51. doi: 10.1080/17588928.2013.838945. Epub 2013 Oct 4.
Abstract
We sought cognitive event-related potential (ERP) biomarkers of "Preclinical Alzheimer's disease" (Pre-AD) using an incidental verbal learning paradigm with high sensitivity to prodromal AD. Seven elderly persons, with normal cognition at the time of ERP recordings, but who showed subsequent cognitive decline or AD pathology at autopsy (n = 5, mean Braak stage = 2.8), were compared to 12 "robust" normal elderly (RNE) persons who remained cognitively normal (Mfollow-up = 9.0 years). EEG was recorded during a word repetition paradigm (semantically congruous (50%) and incongruous target words repeat ~10-140 seconds later). The RNE P600 congruous word repetition ERP effects (New minus Old congruous words) were significantly larger than in Pre-AD (mean amplitudes = 3.28 vs. 0.10 μV, p = .04). High group discrimination (84%) was achieved (by a P600 amplitude cutoff of ~1.5 μV). Abnormal P600 word repetition effects in cognitively normal elderly persons may be an important sign of synaptic dysfunction and Preclinical AD.
摘要
我们使用高敏感的偶发言语学习范式，寻求认知事件相关电位 (ERP) 生物标志物，以诊断“临床前阿尔茨海默病” (Pre-AD)。七名老年人在进行 ERP 记录时认知正常，但随后在尸检中出现认知下降或 AD 病理 (n = 5，平均 Braak 分期 2.8)，与 12 名“健康”正常老年人 (RNE) 进行比较，后者认知正常 (平均随访时间 9.0 年)。在单词重复范式期间记录 EEG (语义一致 (50%) 和不一致的目标单词在 10-140 秒后重复)。RNE 的 P600 一致单词重复 ERP 效应 (新的与旧的一致单词之间的差异) 明显大于 Pre-AD (平均幅度分别为 3.28 μV 和 0.10 μV，p =.04)。高分组判别率 (84%) 达到 (P600 幅度截断值约为 1.5 μV)。认知正常老年人的异常 P600 单词重复效应可能是突触功能障碍和临床前 AD 的重要标志。
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