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本文引用的文献

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Fractionating the word repetition effect with event-related potentials.运用事件相关电位技术分离词语重复效应。
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Brain Potentials during Memory Retrieval Provide Neurophysiological Support for the Distinction between Conscious Recollection and Priming.记忆提取过程中的脑电波为有意识回忆和启动之间的区别提供神经生理学支持。
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Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease.为了定义阿尔茨海默病的临床前阶段：来自美国国家老龄化研究所-阿尔茨海默病协会工作组关于阿尔茨海默病诊断指南的建议。
Alzheimers Dement. 2011 May;7(3):280-92. doi: 10.1016/j.jalz.2011.03.003. Epub 2011 Apr 21.
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Thirty years and counting: finding meaning in the N400 component of the event-related brain potential (ERP).三十年的探索：事件相关脑电位（ERP）中 N400 成分的意义发现。
Annu Rev Psychol. 2011;62:621-47. doi: 10.1146/annurev.psych.093008.131123.
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fMRI responses to words repeated in a congruous semantic context are abnormal in mild Alzheimer's disease.轻度阿尔茨海默病患者在语义一致的语境中重复单词时的 fMRI 反应异常。
Neuropsychologia. 2010 Jul;48(9):2476-87. doi: 10.1016/j.neuropsychologia.2010.04.021. Epub 2010 Apr 28.
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Synaptic targeting by A beta oligomers (ADDLS) as a basis for memory loss in early Alzheimer's disease.β淀粉样蛋白寡聚体（ADDLs）的突触靶向作用作为早期阿尔茨海默病记忆丧失的基础。
Alzheimers Dement. 2006 Jan;2(1):43-55. doi: 10.1016/j.jalz.2005.11.003.
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Event-related fMRI studies of episodic encoding and retrieval: meta-analyses using activation likelihood estimation.情景编码与检索的事件相关功能磁共振成像研究：使用激活可能性估计的元分析
Neuropsychologia. 2009 Jul;47(8-9):1765-79. doi: 10.1016/j.neuropsychologia.2009.02.028. Epub 2009 Mar 4.
8
fMRI congruous word repetition effects reflect memory variability in normal elderly.fMRI 一致性单词重复效应反映了正常老年人记忆的可变性。
Neurobiol Aging. 2010 Nov;31(11):1975-90. doi: 10.1016/j.neurobiolaging.2008.10.010. Epub 2008 Dec 4.
9
Patients with MCI and N400 or P600 abnormalities are at very high risk for conversion to dementia.患有轻度认知障碍且存在N400或P600异常的患者转化为痴呆症的风险非常高。
Neurology. 2008 May 6;70(19 Pt 2):1763-70. doi: 10.1212/01.wnl.0000281689.28759.ab. Epub 2007 Dec 12.
10
Imaging beta-amyloid burden in aging and dementia.衰老和痴呆症中β-淀粉样蛋白负荷的成像
Neurology. 2007 May 15;68(20):1718-25. doi: 10.1212/01.wnl.0000261919.22630.ea.

临床前阿尔茨海默病老年人异常 P600 单词重复效应。

Abnormal P600 word repetition effect in elderly persons with preclinical Alzheimer's disease.

机构信息

a Department of Neurology , University of California , Davis , CA , USA.

出版信息

Cogn Neurosci. 2013;4(3-4):143-51. doi: 10.1080/17588928.2013.838945. Epub 2013 Oct 4.

DOI:10.1080/17588928.2013.838945
PMID:24090465
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3841188/
Abstract

We sought cognitive event-related potential (ERP) biomarkers of "Preclinical Alzheimer's disease" (Pre-AD) using an incidental verbal learning paradigm with high sensitivity to prodromal AD. Seven elderly persons, with normal cognition at the time of ERP recordings, but who showed subsequent cognitive decline or AD pathology at autopsy (n = 5, mean Braak stage = 2.8), were compared to 12 "robust" normal elderly (RNE) persons who remained cognitively normal (Mfollow-up = 9.0 years). EEG was recorded during a word repetition paradigm (semantically congruous (50%) and incongruous target words repeat ~10-140 seconds later). The RNE P600 congruous word repetition ERP effects (New minus Old congruous words) were significantly larger than in Pre-AD (mean amplitudes = 3.28 vs. 0.10 μV, p = .04). High group discrimination (84%) was achieved (by a P600 amplitude cutoff of ~1.5 μV). Abnormal P600 word repetition effects in cognitively normal elderly persons may be an important sign of synaptic dysfunction and Preclinical AD.

摘要

我们使用高敏感的偶发言语学习范式，寻求认知事件相关电位 (ERP) 生物标志物，以诊断“临床前阿尔茨海默病” (Pre-AD)。七名老年人在进行 ERP 记录时认知正常，但随后在尸检中出现认知下降或 AD 病理 (n = 5，平均 Braak 分期 2.8)，与 12 名“健康”正常老年人 (RNE) 进行比较，后者认知正常 (平均随访时间 9.0 年)。在单词重复范式期间记录 EEG (语义一致 (50%) 和不一致的目标单词在 10-140 秒后重复)。RNE 的 P600 一致单词重复 ERP 效应 (新的与旧的一致单词之间的差异) 明显大于 Pre-AD (平均幅度分别为 3.28 μV 和 0.10 μV，p =.04)。高分组判别率 (84%) 达到 (P600 幅度截断值约为 1.5 μV)。认知正常老年人的异常 P600 单词重复效应可能是突触功能障碍和临床前 AD 的重要标志。