Dawson C A, Christensen C W, Rickaby D A, Linehan J H, Johnston M R
J Appl Physiol (1985). 1985 Jun;58(6):1761-6. doi: 10.1152/jappl.1985.58.6.1761.
We examined the influence of glass bead embolization and oleic acid, dextran, and imipramine infusion on the pulmonary uptake of trace doses of [3H]serotonin and the extravascular volume accessible to [14C]antipyrine in anesthetized dogs. Embolization and imipramine decreased serotonin uptake by 53 and 61%, respectively, but no change was observed with oleic acid or dextran infusion. The extravascular volume accessible to the antipyrine was reduced by 77% after embolization and increased by 177 and approximately 44% after oleic acid and dextran infusion, respectively. The results suggest that when the perfused endothelial surface is sufficiently reduced, as with embolization, the uptake of trace doses of serotonin will be depressed. In addition, decreases in serotonin uptake in response to imipramine in this study and in response to certain endothelial toxins in other studies suggest that serotonin uptake can reveal certain kinds of changes in endothelial function. However, the lack of a response to oleic acid-induced damage in the present study suggests that serotonin uptake is not sensitive to all forms of endothelial damage.
我们研究了玻璃珠栓塞以及油酸、右旋糖酐和丙咪嗪输注对麻醉犬肺部微量[3H]血清素摄取以及[14C]安替比林可及的血管外容积的影响。栓塞和丙咪嗪分别使血清素摄取降低了53%和61%，但油酸或右旋糖酐输注后未观察到变化。栓塞后安替比林可及的血管外容积减少了77%，油酸和右旋糖酐输注后分别增加了177%和约44%。结果表明，当灌注的内皮表面充分减少时，如栓塞时，微量血清素的摄取会受到抑制。此外，本研究中丙咪嗪引起的血清素摄取减少以及其他研究中某些内皮毒素引起的血清素摄取减少表明，血清素摄取可以揭示内皮功能的某些变化。然而，本研究中对油酸诱导的损伤缺乏反应表明，血清素摄取并非对所有形式的内皮损伤都敏感。
