Takeda A, Okumura S, Miyamoto T, Hagio M, Fujinaga T
Department of Veterinary Surgery, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
J Vet Med Sci. 1995 Jun;57(3):481-5. doi: 10.1292/jvms.57.481.
The relationship between extravascular lung water volume (ELWV) and chest radiographical findings was studied in general-anesthetized beagles. The dogs were experimentally injected with oleic acid to increase pulmonary vascular permeability. When the ELWV value in the dogs increased more than approximately 37% from the control value, their chest radiographs began to show signs of pulmonary edema. At this time, the chest X-ray density increased to 10% above the control level. PaO2 decreased, and PaCO2 increased after the administration of oleic acid. This clearly showed that the pulmonary gas exchange function was reduced following increasing ELWV. This comparison showed that probably the thermal-sodium double indicator dilution measurement of ELWV can detect slight hyperpermeability pulmonary edema that does not show on chest radiographs. The chest radiograph was therefore not suitable for the detection of slight pulmonary edema, because it did not show any changes in the early stages in hyperpermeability pulmonary edema.
在全身麻醉的比格犬中研究了血管外肺水容量（ELWV）与胸部X线表现之间的关系。通过实验给这些犬注射油酸以增加肺血管通透性。当犬的ELWV值较对照值增加超过约37%时，其胸部X线片开始显示肺水肿的征象。此时，胸部X线密度增加至高于对照水平10%。注射油酸后，动脉血氧分压（PaO2）降低，动脉血二氧化碳分压（PaCO2）升高。这清楚地表明随着ELWV增加，肺气体交换功能降低。该比较表明，ELWV的热-钠双指示剂稀释测量可能能够检测出胸部X线片上未显示的轻度通透性肺水肿。因此，胸部X线片不适合用于检测轻度肺水肿，因为在通透性肺水肿的早期阶段它未显示任何变化。
