儿童在产前暴露于抗癫痫药物后的学龄前行为问题 - 一项随访研究。

Preschool behavioral problems in children prenatally exposed to antiepileptic drugs - a follow-up study.

机构信息

Section for Epidemiology, Department of Public Health, Aarhus University, Denmark; Department of Pathology, Aarhus University Hospital, Denmark; Department of Clinical Pharmacology, Aarhus University Hospital, Denmark.

出版信息

Epilepsy Behav. 2013 Nov;29(2):407-11. doi: 10.1016/j.yebeh.2013.08.033. Epub 2013 Oct 3.

DOI:10.1016/j.yebeh.2013.08.033

PMID:24090777

Abstract

We studied the association between maternal epilepsy, antiepileptic drug (AED) treatment, and behavioral problems in preschool children. In the Danish National Birth Cohort, we identified 4- to 5-year-old children whose mothers had epilepsy and received AED treatment (n=133) or not (n=304) during pregnancy and compared them with randomly selected children whose mothers did not have epilepsy (n=1193). The children's behavioral problems were assessed by the use of the Strengths and Difficulties Questionnaire (SDQ). Children prenatally exposed to AEDs more often had an abnormal total SDQ score as compared with children of women without epilepsy (odds ratio (OR)=4.8 (95% CI: 1.9-12.1)) and as compared with children of women with epilepsy who were not treated with AEDs during their pregnancy (OR=4.0 (95% CI: 1.3-12.8)). In conclusion, prenatal AED exposure may increase the risk of behavioral problems in preschool children even after adjustments for potential confounders and maternal epilepsy.

摘要

我们研究了母亲癫痫、抗癫痫药物（AED）治疗与学龄前儿童行为问题之间的关联。在丹麦全国出生队列中，我们确定了在妊娠期间患有癫痫并接受 AED 治疗（n=133）或未接受治疗（n=304）的 4 至 5 岁儿童，并将其与随机选择的未患有癫痫的母亲的儿童（n=1193）进行了比较。使用长处和困难问卷（SDQ）评估了儿童的行为问题。与未患有癫痫的母亲的儿童相比，产前暴露于 AED 的儿童的 SDQ 总分异常的发生率更高（比值比（OR）=4.8（95%CI：1.9-12.1）），与妊娠期间未接受 AED 治疗的患有癫痫的母亲的儿童相比，OR=4.0（95%CI：1.3-12.8）。总之，即使在调整了潜在混杂因素和母亲癫痫后，产前 AED 暴露也可能增加学龄前儿童行为问题的风险。