Department of Organismal Biology and Anatomy, The University of Chicago, 1027 E 57th Street, Chicago, IL 60637, United States.
Curr Opin Neurobiol. 2013 Dec;23(6):943-50. doi: 10.1016/j.conb.2013.09.001. Epub 2013 Sep 30.
During development, the migration of specific neuronal subtypes is required for the correct establishment of neural circuits. In mice and zebrafish, facial branchiomotor (FBM) neurons undergo a tangential migration from rhombomere 4 caudally through the hindbrain. Recent advances in the field have capitalized on genetic studies in zebrafish and mouse, and high-resolution time-lapse imaging in zebrafish. Planar cell polarity signaling has emerged as a critical conserved factor in FBM neuron migration, functioning both within the neurons and their environment. In zebrafish, migration depends on specialized 'pioneer' neurons to lead follower FBM neurons through the hindbrain, and on interactions with structural components including pre-laid axon tracts and the basement membrane. Despite fundamental conservation, species-specific differences in migration mechanisms are being uncovered.
在发育过程中，特定神经元亚型的迁移对于神经回路的正确建立是必需的。在小鼠和斑马鱼中，面部运动神经元（FBM）从菱形 4 尾部经后脑进行切线迁移。该领域的最新进展利用了斑马鱼和小鼠的遗传研究，以及斑马鱼的高分辨率延时成像。平面细胞极性信号转导已成为 FBM 神经元迁移的一个关键保守因素，在神经元及其环境中均发挥作用。在斑马鱼中，迁移依赖于专门的“先驱”神经元来引导后续 FBM 神经元通过后脑，并依赖于与结构成分的相互作用，包括预先铺设的轴突束和基底膜。尽管存在基本的保守性，但在迁移机制方面仍存在物种特异性差异。
