移动细胞中的平面细胞极性：全局思考，局部行动。
Planar cell polarity in moving cells: think globally, act locally.
作者信息
Davey Crystal F, Moens Cecilia B
机构信息
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, B2-159, 1100 Fairview Ave. N., Seattle, WA 98109, USA.
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, B2-159, 1100 Fairview Ave. N., Seattle, WA 98109, USA
出版信息
Development. 2017 Jan 15;144(2):187-200. doi: 10.1242/dev.122804.
Abstract
The planar cell polarity (PCP) pathway is best known for its role in polarizing epithelial cells within the plane of a tissue but it also plays a role in a range of cell migration events during development. The mechanism by which the PCP pathway polarizes stationary epithelial cells is well characterized, but how PCP signaling functions to regulate more dynamic cell behaviors during directed cell migration is much less understood. Here, we review recent discoveries regarding the localization of PCP proteins in migrating cells and their impact on the cell biology of collective and individual cell migratory behaviors.
摘要
平面细胞极性（PCP）通路最为人所知的是其在组织平面内使上皮细胞极化的作用，但它在发育过程中的一系列细胞迁移事件中也发挥作用。PCP通路使静止上皮细胞极化的机制已得到充分表征，但PCP信号在定向细胞迁移过程中如何调节更动态的细胞行为却知之甚少。在这里，我们综述了关于PCP蛋白在迁移细胞中的定位及其对集体和单个细胞迁移行为的细胞生物学影响的最新发现。
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本文引用的文献
1
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Elife. 2016 Sep 23;5:e16463. doi: 10.7554/eLife.16463.
2
A lateral signalling pathway coordinates shape volatility during cell migration.侧向信号通路协调细胞迁移过程中的形状变化。
Nat Commun. 2016 May 26;7:11714. doi: 10.1038/ncomms11714.
3
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PLoS Genet. 2016 Mar 18;12(3):e1005934. doi: 10.1371/journal.pgen.1005934. eCollection 2016 Mar.
4
PLD1 regulates Xenopus convergent extension movements by mediating Frizzled7 endocytosis for Wnt/PCP signal activation.磷脂酶D1通过介导卷曲蛋白7的内吞作用以激活Wnt/平面细胞极性信号，从而调控非洲爪蟾的汇聚延伸运动。
Dev Biol. 2016 Mar 1;411(1):38-49. doi: 10.1016/j.ydbio.2016.01.013. Epub 2016 Jan 21.
5
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6
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