热带念珠菌引起的手指甲真菌病：短脉冲钕：钇铝石榴石激光治疗
[Finger onychomycosis due to Candida tropicalis: short-pulsed Nd:YAG laser therapy].
作者信息
Naouri M, Mazer J-M
机构信息
Cabinet de dermatologie, centre Laser, 4, place du Général Leclerc, 94130 Nogent-sur-Marne, France; Centre Laser international de la peau de Paris (CLIPP), 85, avenue de la Bourdonnais, 75007 Paris, France.
出版信息
Ann Dermatol Venereol. 2013 Oct;140(10):610-3. doi: 10.1016/j.annder.2013.04.079. Epub 2013 May 24.
BACKGROUND
Treatment options for onychomycosis are numerous but of limited efficacy, potentially dangerous and/or relatively restrictive.
PATIENTS AND METHODS
We describe the first case of Candida tropicalis onychomycosis resistant to standard topical treatments successfully treated with four sessions of Nd:YAG laser in Short Pulse mode. The efficacy of treatment was verified at 3 months via a negative control sample and was maintained for at least 6 months.
DISCUSSION
Nd:YAG laser is a versatile type of laser widely used in dermatology. Its mode of action in the treatment of onychomycosis may consist of a thermal effect that is non-specific but differentiates between healthy nail and diseased nail, which respond differently to impact. The main interest of this case is in helping to pave the way for a new type of treatment for onychomycosis.
背景
甲癣的治疗方法众多，但疗效有限，存在潜在危险和/或限制相对较多。
患者与方法
我们描述了首例热带念珠菌性甲癣病例，该病例对标准局部治疗耐药，采用短脉冲模式的Nd:YAG激光进行了四个疗程的治疗，成功治愈。在3个月时通过阴性对照样本验证了治疗效果，且该效果维持了至少6个月。
讨论
Nd:YAG激光是一种在皮肤科广泛应用的多功能激光。其治疗甲癣的作用方式可能包括一种非特异性的热效应，该效应能区分健康指甲和患病指甲，二者对热效应的反应不同。该病例的主要意义在于为甲癣的新型治疗方法铺平道路。
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