Wall Geoffrey C, Nayima Vuong A, Neumeister Kristen M
J Chemother. 2014 Jun;26(3):150-3. doi: 10.1179/1973947813Y.0000000127. Epub 2013 Dec 6.
The use of carbapenem antibacterials in patients with a claimed history of penicillin allergy is somewhat controversial. This study aimed to examine the rates of presumed hypersensitivity reactions in a large cohort of patients receiving carbapenem antibiotics.
A retrospective chart review was performed on all adult patients who received a carbapenem in a teaching hospital from June 2011 to June 2012. Information procured included listed penicillin allergy and reaction if known, type of carbapenem received, and any allergic reaction during that admission.
Nine-hundred and fifty eight patients who received a carbapenem antimicrobial were reviewed. Five patients developed a presumed reaction to carbapenem: one in the penicillin allergy group and four in the non-allergic group. There were no statistical or numerical differences in rates of reaction between the two groups.
Patients with a claimed history of penicillin allergy were not more likely to develop a presumed hypersensitivity reaction to a carbapenem compared to those who did not claim such an allergy.
在有青霉素过敏史的患者中使用碳青霉烯类抗菌药物存在一定争议。本研究旨在调查一大群接受碳青霉烯类抗生素治疗的患者中推测的超敏反应发生率。
对2011年6月至2012年6月在一家教学医院接受碳青霉烯类药物治疗的所有成年患者进行回顾性病历审查。获取的信息包括列出的青霉素过敏情况及已知的反应、所接受的碳青霉烯类药物类型以及该次住院期间的任何过敏反应。
对958例接受碳青霉烯类抗菌药物治疗的患者进行了审查。5例患者出现了推测的对碳青霉烯类药物的反应：青霉素过敏组1例，非过敏组4例。两组之间的反应发生率在统计学上或数值上均无差异。
与没有青霉素过敏史的患者相比，有青霉素过敏史的患者对碳青霉烯类药物发生推测的超敏反应的可能性并不更高。
