Federal Institute for Occupational Safety and Health, Friedrich-Henkel-Weg 1-25, 44149, Dortmund, Germany.
Arch Toxicol. 2013 Nov;87(11):2027-2029. doi: 10.1007/s00204-013-1139-9. Epub 2013 Oct 5.
The evaluations in Gebel (Arch Toxicol 86(7):995-1007, 2012) were carried out according to established procedures in regulatory toxicology. The variability in the available data was taken into account. The quality of the underlying data set should not be overestimated. The relevant conclusion in Gebel (Arch Toxicol 86(7):995-1007, 2012) is that the difference in carcinogenic potency comparing nanosized to microsized respirable granular biodurable particles without known significant specific toxicity (GBP) is low and lower than previously estimated.
格尔贝尔（Arch Toxicol 86(7):995-1007, 2012）的评估是按照监管毒理学的既定程序进行的。考虑到了可用数据的变异性。不应过高估计基础数据集的质量。格尔贝尔（Arch Toxicol 86(7):995-1007, 2012）的相关结论是，与已知无显著特异性毒性的纳米尺寸与微米尺寸可呼吸颗粒生物持久性颗粒（GBP）相比，纳米尺寸可呼吸颗粒的致癌效力差异较低，且低于之前的估计。
