Payan D G, Goetzl E J
J Immunol. 1985 Aug;135(2 Suppl):783s-786s.
Neuropeptides present in the peripheral nervous system (PNS) and central nervous system (CNS) modify diverse functions of human, murine and guinea pig mononuclear leukocytes in vitro and in vivo by receptor-mediated mechanisms. Both stimulatory and inhibitory effects on lymphocytes and macrophages have been demonstrated for different neuropeptides in vitro at concentrations which are similar to those in the circulation and in tissues. The dissociation constant (KD) for the binding of a neuropeptide to its lymphocyte receptor is within the range of concentrations that evoke lymphocyte responses critical to immunity and hypersensitivity. The receptor-mediated interactions of diverse neuropeptides with immunocompetent cells provide one mechanism through which the PNS may influence localized immune responses and the CNS may alter systemic immunity.
存在于外周神经系统（PNS）和中枢神经系统（CNS）中的神经肽，通过受体介导机制在体外和体内改变人、小鼠和豚鼠单核白细胞的多种功能。在体外，不同神经肽对淋巴细胞和巨噬细胞的刺激和抑制作用都已在与循环和组织中相似的浓度下得到证实。神经肽与其淋巴细胞受体结合的解离常数（KD）处于引发对免疫和超敏反应至关重要的淋巴细胞反应的浓度范围内。多种神经肽与免疫活性细胞的受体介导相互作用提供了一种机制，通过该机制PNS可能影响局部免疫反应，而CNS可能改变全身免疫。
