Partsch G, Matucci-Cerinic M
Ludwig Boltzmann Institute of Rheumatology and Balneology, Vienna-Oberlaa, Austria.
Inflammation. 1992 Oct;16(5):539-47. doi: 10.1007/BF00918978.
The effects of the two neuropeptides, substance P (SP) and somatostatin (SOM), on the migration of polymorphonuclear cells derived from 13 volunteers were investigated. The neuropeptides were applied in concentrations between 10(-12) and 10(-6) M. Only at a concentration of 10(-6) M SP did the chemotaxis of PMN cells increase slightly but statistically significantly. In contrast to SP, SOM showed a significant dose-dependent stimulation of chemotaxis, which was first traceable at 10(-10) M and increased up to 10(-6) M. Although it is uncertain whether in vivo SP and SOM contribute directly to the invasion of PMN cells into the joint cavity, the influence of these neuropeptides on PMN migration in vitro is a further indication of the neuropeptide involvement in the genesis of inflammation.
研究了两种神经肽，即P物质（SP）和生长抑素（SOM）对来自13名志愿者的多形核细胞迁移的影响。神经肽的应用浓度范围为10^(-12)至10^(-6) M。仅在10^(-6) M的SP浓度下，PMN细胞的趋化性略有增加，但具有统计学意义。与SP相反，SOM表现出显著的剂量依赖性趋化性刺激，在10^(-10) M时首次可检测到，并增加至10^(-6) M。尽管尚不确定体内SP和SOM是否直接促进PMN细胞侵入关节腔，但这些神经肽对体外PMN迁移的影响进一步表明神经肽参与了炎症的发生。
