Buendia A J, Peñafiel-Verdu C, Navarro J A, Vilafranca M, Sanchez J
Departamento de Anatomía y Anatomía Patológica Comparadas, Facultad de Veterinaria, Universidad de Murcia, Murcia, Spain
Departamento de Anatomía y Anatomía Patológica Comparadas, Facultad de Veterinaria, Universidad de Murcia, Murcia, Spain.
Vet Pathol. 2014 Jul;51(4):755-8. doi: 10.1177/0300985813505115. Epub 2013 Oct 3.
The cadherin family of adhesion molecules regulates cell-cell interactions. N-cadherin is expressed by neural and fibroblast cells but not by normal epithelial cells. In human medicine, the role of N-cadherin in breast cancer remains controversial, but some studies have described the switch from E-cadherin to N-cadherin as a critical step in the malignant progression of neoplastic cells. The present study was carried out on 160 feline mammary tumors (21 adenomas and 139 carcinomas). The relationship between the immunohistochemical expression of N-cadherin in neoplastic epithelial cells and 2 established prognostic factors such as regional metastasis and tumor grade was examined. The results of the study showed a statistically significant relation between the expression of N-cadherin and the 2 prognostic factors, and also a reduced expression of E-cadherin in tumors that expressed N-cadherin.
钙黏蛋白家族的黏附分子调节细胞间相互作用。N-钙黏蛋白由神经细胞和成纤维细胞表达，但正常上皮细胞不表达。在人类医学中，N-钙黏蛋白在乳腺癌中的作用仍存在争议，但一些研究将从E-钙黏蛋白向N-钙黏蛋白的转变描述为肿瘤细胞恶性进展的关键步骤。本研究对160例猫乳腺肿瘤（21例腺瘤和139例癌）进行。研究了肿瘤上皮细胞中N-钙黏蛋白的免疫组化表达与区域转移和肿瘤分级这两个既定预后因素之间的关系。研究结果显示N-钙黏蛋白的表达与这两个预后因素之间存在统计学上的显著关系，并且在表达N-钙黏蛋白的肿瘤中E-钙黏蛋白的表达降低。
