Peñafiel-Verdu C, Buendia A J, Navarro J A, Ramirez G A, Vilafranca M, Altimira J, Sanchez J
Departamento de Anatomía y Anatomía Patológica Comparadas, Facultad de Veterinaria, Universidad de Murcia, Campus de Espinardo, 30100 Murcia, Spain.
Vet Pathol. 2012 Nov;49(6):979-87. doi: 10.1177/0300985812436744. Epub 2012 Feb 15.
Feline mammary carcinomas are highly aggressive neoplasms. Several mechanisms are thought to be involved in their progression, including the loss of epithelial adhesion molecules. The present study was carried out on 21 adenomas and 139 mammary carcinomas. Of the carcinomas, 66 were not reported to have metastasized, while the remaining 73 had evidence of regional lymph node metastasis at the moment of diagnosis. The relationship was examined between the expression of the E-cadherin-β-catenin complex and basal (CK5/6, CK14) and luminal (CK8/18) cytokeratin expression. In the medical literature, carcinomas expressing basal cytokeratins are reported as having a poor prognosis in human breast cancer. Results revealed that preservation of the expression of E-cadherin and β-catenin is a significant feature of carcinomas without metastasis, whereas carcinomas with metastasis reveal the loss of one or both adhesion molecules. Additionally, basal cytokeratin expression was statistically associated with the presence of regional metastasis. Furthermore, the expression of E-cadherin-β-catenin was significantly correlated with the high expression of CK18 and low expression of CK5/6.
猫乳腺肿瘤是具有高度侵袭性的肿瘤。其进展被认为涉及多种机制，包括上皮黏附分子的缺失。本研究对21例腺瘤和139例乳腺癌进行了分析。在这些癌中，66例未报告有转移，而其余73例在诊断时已有区域淋巴结转移的证据。研究了E-钙黏蛋白-β-连环蛋白复合物的表达与基底（CK5/6、CK14）和管腔（CK8/18）细胞角蛋白表达之间的关系。在医学文献中，表达基底细胞角蛋白的癌在人类乳腺癌中被报道预后较差。结果显示，E-钙黏蛋白和β-连环蛋白表达的保留是无转移癌的一个显著特征，而有转移的癌则显示一种或两种黏附分子的缺失。此外，基底细胞角蛋白的表达与区域转移的存在在统计学上相关。此外，E-钙黏蛋白-β-连环蛋白的表达与CK18的高表达和CK5/6的低表达显著相关。
