青蛙缝匠肌在不同pH水平下终板电流的幅度和时程。
The amplitude and the time course of the end-plate current at various pH levels in the frog sartorius muscle.
作者信息
Scuka M
出版信息
J Physiol. 1975 Jul;249(2):183-95. doi: 10.1113/jphysiol.1975.sp011010.
Abstract
- The amplitude and the time course of the end-plate current are dependent on the pH of the bathing solution. 2. When pH is changed from 5.4 to 9.4 the amplitude of the end-plate current is increased and its decay is speeded up. 3. The change in the amplitude seems to be a result of a variation of quantal content. 4. The change in the time course of the end-plate current is explained by assuming that the rate constants which determine the dissociation of the receptor-mediator complex are affected by a change in pH. 5. This speculation is supported by the finding that the effect of membrane potential on amplitude and time course of the end-plate current are dependent on pH of the bathing solution.
摘要
- 终板电流的幅度和时程取决于灌流液的pH值。2. 当pH值从5.4变为9.4时，终板电流的幅度增大，其衰减加速。3. 幅度的变化似乎是量子含量变化的结果。4. 终板电流时程的变化是通过假设决定受体 - 介质复合物解离的速率常数受pH值变化影响来解释的。5. 膜电位对终板电流幅度和时程的影响取决于灌流液的pH值这一发现支持了这一推测。
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