The amplitude and the time course of the end-plate current at various pH levels in the frog sartorius muscle.
作者信息
Scuka M
出版信息
J Physiol. 1975 Jul;249(2):183-95. doi: 10.1113/jphysiol.1975.sp011010.
Abstract
- The amplitude and the time course of the end-plate current are dependent on the pH of the bathing solution. 2. When pH is changed from 5.4 to 9.4 the amplitude of the end-plate current is increased and its decay is speeded up. 3. The change in the amplitude seems to be a result of a variation of quantal content. 4. The change in the time course of the end-plate current is explained by assuming that the rate constants which determine the dissociation of the receptor-mediator complex are affected by a change in pH. 5. This speculation is supported by the finding that the effect of membrane potential on amplitude and time course of the end-plate current are dependent on pH of the bathing solution.
摘要
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本文引用的文献
1
An analysis of the end-plate potential recorded with an intracellular electrode.
J Physiol. 1951 Nov 28;115(3):320-70. doi: 10.1113/jphysiol.1951.sp004675.
2
On the localization of acetylcholine receptors.
J Physiol. 1955 Apr 28;128(1):157-81. doi: 10.1113/jphysiol.1955.sp005297.
3
[THE EFFECT OF H-IONS ON THE ELECTROLYTE CONTENT, MEMBRANE POTENTIAL AND CONTRACTION OF TONIC AND PHASIC SKELETAL MUSCLE].
Pflugers Arch Gesamte Physiol Menschen Tiere. 1964 Jun 9;280:1-21.
4
EFFECT OF PH ON THE RESTING MEMBRANE POTENTIAL OF FROG SARTORIUS MUSCLE.
J Cell Comp Physiol. 1964 Jun;63:359-64. doi: 10.1002/jcp.1030630311.
5
Mechanism of the increased acetylcholine sensitivity of skeletal muscle in low pH solutions.
J Cell Comp Physiol. 1962 Feb;59:35-44. doi: 10.1002/jcp.1030590105.
6
Active phase of frog's end-plate potential.
J Neurophysiol. 1959 Jul;22(4):395-411. doi: 10.1152/jn.1959.22.4.395.
7
The effect of temperature on the neuromuscular junction of the frog.
Jpn J Physiol. 1958 Dec 20;8(4):391-404. doi: 10.2170/jjphysiol.8.391.
8
Affinity, intrinsic activity and drug interactions.
Pharmacol Rev. 1957 Jun;9(2):218-36.
9
A further study of the statistical composition on the end-plate potential.
J Physiol. 1955 Oct 28;130(1):114-22. doi: 10.1113/jphysiol.1955.sp005397.
10
The relationship of quaternary ammonium salts to the anionic sites of true and pseudo cholinesterase.
Biochem J. 1954 Dec;58(4):692-8. doi: 10.1042/bj0580692.
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