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青蛙缝匠肌在不同pH水平下终板电流的幅度和时程。

The amplitude and the time course of the end-plate current at various pH levels in the frog sartorius muscle.

作者信息

Scuka M

出版信息

J Physiol. 1975 Jul;249(2):183-95. doi: 10.1113/jphysiol.1975.sp011010.

DOI:10.1113/jphysiol.1975.sp011010
PMID:240926
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1309569/
Abstract
  1. The amplitude and the time course of the end-plate current are dependent on the pH of the bathing solution. 2. When pH is changed from 5.4 to 9.4 the amplitude of the end-plate current is increased and its decay is speeded up. 3. The change in the amplitude seems to be a result of a variation of quantal content. 4. The change in the time course of the end-plate current is explained by assuming that the rate constants which determine the dissociation of the receptor-mediator complex are affected by a change in pH. 5. This speculation is supported by the finding that the effect of membrane potential on amplitude and time course of the end-plate current are dependent on pH of the bathing solution.
摘要
  1. 终板电流的幅度和时程取决于灌流液的pH值。2. 当pH值从5.4变为9.4时，终板电流的幅度增大，其衰减加速。3. 幅度的变化似乎是量子含量变化的结果。4. 终板电流时程的变化是通过假设决定受体 - 介质复合物解离的速率常数受pH值变化影响来解释的。5. 膜电位对终板电流幅度和时程的影响取决于灌流液的pH值这一发现支持了这一推测。

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本文引用的文献

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An analysis of the end-plate potential recorded with an intracellular electrode.用细胞内电极记录的终板电位分析。
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On the localization of acetylcholine receptors.关于乙酰胆碱受体的定位
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[THE EFFECT OF H-IONS ON THE ELECTROLYTE CONTENT, MEMBRANE POTENTIAL AND CONTRACTION OF TONIC AND PHASIC SKELETAL MUSCLE].[氢离子对强直性和相性骨骼肌的电解质含量、膜电位及收缩的影响]
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EFFECT OF PH ON THE RESTING MEMBRANE POTENTIAL OF FROG SARTORIUS MUSCLE.pH对青蛙缝匠肌静息膜电位的影响。
J Cell Comp Physiol. 1964 Jun;63:359-64. doi: 10.1002/jcp.1030630311.
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Mechanism of the increased acetylcholine sensitivity of skeletal muscle in low pH solutions.低pH溶液中骨骼肌乙酰胆碱敏感性增加的机制。
J Cell Comp Physiol. 1962 Feb;59:35-44. doi: 10.1002/jcp.1030590105.
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Active phase of frog's end-plate potential.青蛙终板电位的活动期
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7
The effect of temperature on the neuromuscular junction of the frog.温度对青蛙神经肌肉接头的影响。
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8
Affinity, intrinsic activity and drug interactions.亲和力、内在活性与药物相互作用。
Pharmacol Rev. 1957 Jun;9(2):218-36.
9
A further study of the statistical composition on the end-plate potential.关于终板电位统计构成的进一步研究。
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10
The relationship of quaternary ammonium salts to the anionic sites of true and pseudo cholinesterase.季铵盐与真性及假性胆碱酯酶阴离子位点的关系。
Biochem J. 1954 Dec;58(4):692-8. doi: 10.1042/bj0580692.