School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taiwan ; Physical Therapy Center, National Taiwan University Hospital, Taipei, Taiwan.
Onco Targets Ther. 2013 Sep 16;9:1277-83. doi: 10.2147/OTT.S50869. eCollection 2013.
The functional exercise capacity and its correlates in advanced cancer patients in stratified age groups were examined.
A total of 105 patients with advanced lung cancer were recruited prospectively and stratified into young (≤50 years), middle (51-65 years), and old (>65 years) age groups. Respiratory performances, which included maximal inspiratory and expiratory pressure, forced expiratory volume in 1 second, and forced vital capacity were measured. The distance ambulated in a 6-minute walk test was used as an indicator for functional capacity.
The young age group had lowest baseline pulmonary function and performed worse on the 6-minute walk test among the three age groups. The risk factors for poor functional capacity were female, lower percent predicted maximal expiratory pressure, worse dyspnea, and lower hemoglobin in the young age group; lower percent predicated forced expiratory volume in 1 second and forced vital capacity, and greater weight loss in the middle age group; and only worse dyspnea in the old age group. The above identified risk factors accounted for 73.6%, 58.5%, and 42.1% variance in 6-minute walk distance for the young, middle, and old age group, respectively.
The impacts of these factors on functional exercise capacity should be carefully considered while designing exercise intervention according to age.
本研究旨在探讨不同年龄分层的晚期癌症患者的功能运动能力及其相关因素。
前瞻性招募了 105 名晚期肺癌患者，并按年龄分为青年组（≤50 岁）、中年组（51-65 岁）和老年组（>65 岁）。测量了呼吸功能，包括最大吸气和呼气压力、1 秒用力呼气量和用力肺活量。6 分钟步行试验所走的距离被用作功能能力的指标。
在三组年龄中，青年组的基础肺功能最低，6 分钟步行试验的表现最差。功能能力差的危险因素为女性、较低的最大呼气压力预计值、更严重的呼吸困难以及较低的血红蛋白，在青年组；较低的 1 秒用力呼气量预计值和用力肺活量，以及体重减轻较多，在中年组；而在老年组仅为更严重的呼吸困难。上述确定的危险因素分别占青年、中年和老年组 6 分钟步行距离方差的 73.6%、58.5%和 42.1%。
在根据年龄设计运动干预措施时，应仔细考虑这些因素对功能运动能力的影响。
