Department of Epidemiology and Biostatistics, Case Western Reserve University Cleveland, OH, USA.
Front Genet. 2013 Sep 25;4:189. doi: 10.3389/fgene.2013.00189. eCollection 2013.
A novel web-based tool PedWiz that pipelines the informatics process for pedigree data is introduced. PedWiz is designed to assist researchers in the analysis of pedigree data. It provides a convenient tool for pedigree informatics: descriptive statistics, relative pairs, genetic similarity coefficients, the variance-covariance matrix for three estimated coefficients of allele identical-by-descent sharing as well as mean allele sharing, a plot of the pedigree structures, and a visualization of the identity coefficients. With a renewed interest in linkage and other family based methods, PedWiz will be a valuable tool for the analysis of family data.
介绍了一种新颖的基于网络的工具 PedWiz,它为系谱数据的信息学过程提供了管道。PedWiz 旨在协助研究人员分析系谱数据。它为系谱信息学提供了一个方便的工具:描述性统计、相对对、遗传相似系数、三个估计的等位基因相同遗传共享系数的方差-协方差矩阵以及平均等位基因共享、系谱结构图和身份系数的可视化。随着对连锁和其他基于家族的方法的重新关注,PedWiz 将成为分析家族数据的有价值的工具。