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pedantics:一个基于系谱的遗传模拟和系谱操作、特征描述和查看的 R 包。

pedantics: an r package for pedigree-based genetic simulation and pedigree manipulation, characterization and viewing.

机构信息

Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, King's Buildings, West Mains Road, Edinburgh EH9 3JT, UK.

出版信息

Mol Ecol Resour. 2010 Jul;10(4):711-9. doi: 10.1111/j.1755-0998.2009.02817.x. Epub 2009 Dec 16.

DOI:10.1111/j.1755-0998.2009.02817.x
PMID:21565076
Abstract

Analyses of pedigrees and pedigree-derived parameters (e.g. relatedness and fitness) provide some of the most informative types of studies in evolutionary biology. The r package pedantics implements tools to facilitate power and sensitivity analyses of pedigree-related studies of natural populations. Functions are available to permute pedigree data in various ways with the goal of mimicking patterns of pedigree errors and missingness that occur in studies of natural populations. Another set of functions simulates genetic and phenotypic data based on arbitrary pedigrees. Finally, functions are also available with which visual and numerical representations of pedigree structure can be generated.

摘要

家系分析和基于家系的参数分析(如亲缘关系和适合度)为进化生物学提供了最有价值的研究类型之一。r 包 pedantics 实现了工具,以方便自然种群的家系相关研究的功效和灵敏度分析。该函数可通过各种方式对家系数据进行置换,目的是模拟自然种群研究中出现的家系错误和缺失模式。另一组函数可基于任意家系模拟遗传和表型数据。最后,还提供了生成家系结构的可视化和数值表示的函数。

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