软组织肉瘤的新兴疗法。

Emerging therapies for soft-tissue sarcomas.

机构信息

Department of Medical Oncology, Léon Bérard Cancer Center, 28 rue Laennec, Lyon 69008, France.

出版信息

Hematol Oncol Clin North Am. 2013 Oct;27(5):1063-78. doi: 10.1016/j.hoc.2013.07.011.

DOI:10.1016/j.hoc.2013.07.011

Abstract

Sarcomas are heterogeneous group of tumors that arise from tissues of mesenchymal origin. Current options for patients with advanced disease are limited, and only 2 drugs have been approved for these diseases over the last decade. Although several drugs are currently under development for soft-tissue sarcoma as a whole, improved understanding of sarcoma biology has led to the emergence of subtype-specific targeted therapy. This article reviews recent clinical data on emerging therapies for soft-tissue sarcoma.

摘要

肉瘤是一组来源于间充质组织的异质性肿瘤。目前，晚期疾病患者的选择有限，在过去十年中，仅有 2 种药物被批准用于这些疾病。尽管目前正在开发几种用于软组织肉瘤整体的药物，但对肉瘤生物学的深入了解导致了亚型特异性靶向治疗的出现。本文综述了软组织肉瘤新兴治疗方法的最新临床数据。