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维生素 D 受体多态性对尿石症风险的影响：一项荟萃分析。

Effects of vitamin D receptor polymorphisms on urolithiasis risk: a meta-analysis.

机构信息

Department of Nephrology, the First People's Hospital of Jingzhou City, the First Hospital of Yangtze University, Jingzhou, Hubei Province 434000, China.

出版信息

BMC Med Genet. 2013 Oct 6;14:104. doi: 10.1186/1471-2350-14-104.

DOI:10.1186/1471-2350-14-104
PMID:24093218
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3850980/
Abstract

BACKGROUND

Several studies analyzed the associations of Vitamin D receptor (VDR) polymorphisms with urolithiasis risk in different ethnic groups. However, the results were inconclusive. To evaluate a more precise estimation of the relationship, a meta-analysis was performed.

METHODS

Pubmed, EMBASE, Wanfang Database, China National Knowledge Infrastructure (CNKI) and Weipu Database were searched. Data were extracted independently by two investigators. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations.

RESULTS

Twenty-three case-control studies were included in this meta-analysis. Significant associations between ApaI, BsmI, FokI, and TaqI polymorphisms and urolithiasis risk were observed. However, sensitivity analyses for BsmI and FokI polymorphisms indicated that the results were not reliable and credible. In addition, there was a significant association of the ApaI-TaqI haplotype with urolithiasis risk.

CONCLUSIONS

This meta-analysis suggested that ApaI and TaqI polymorphisms in VDR gene were associated with urolithiasis risk.

摘要

背景

多项研究分析了维生素 D 受体 (VDR) 多态性与不同人群尿石症风险的相关性，但结果不一致。为了更准确地评估这种关系，进行了荟萃分析。

方法

检索 Pubmed、EMBASE、万方数据库、中国知网 (CNKI) 和维普数据库。由两位研究者独立提取数据。使用比值比 (OR) 和 95%置信区间 (CI) 来评估关联的强度。

结果

本荟萃分析纳入了 23 项病例对照研究。ApaI、BsmI、FokI 和 TaqI 多态性与尿石症风险之间存在显著相关性。然而，BsmI 和 FokI 多态性的敏感性分析表明，结果不可靠和可信。此外，ApaI-TaqI 单倍型与尿石症风险显著相关。

结论

本荟萃分析提示 VDR 基因的 ApaI 和 TaqI 多态性与尿石症风险相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c65/3850980/da7fb156df0e/1471-2350-14-104-11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c65/3850980/f479491e9475/1471-2350-14-104-1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c65/3850980/639eedd8c226/1471-2350-14-104-5.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c65/3850980/59e6b14feec8/1471-2350-14-104-10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c65/3850980/da7fb156df0e/1471-2350-14-104-11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c65/3850980/f479491e9475/1471-2350-14-104-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c65/3850980/bd407ff69f64/1471-2350-14-104-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c65/3850980/6393bda955ed/1471-2350-14-104-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c65/3850980/15a2845de65d/1471-2350-14-104-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c65/3850980/639eedd8c226/1471-2350-14-104-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c65/3850980/145c260564c5/1471-2350-14-104-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c65/3850980/421fcc5e6407/1471-2350-14-104-7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c65/3850980/5db79b241a13/1471-2350-14-104-8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c65/3850980/418c55972786/1471-2350-14-104-9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c65/3850980/59e6b14feec8/1471-2350-14-104-10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c65/3850980/da7fb156df0e/1471-2350-14-104-11.jpg

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