Department of Respiratory Disease, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.
PLoS One. 2012;7(7):e42062. doi: 10.1371/journal.pone.0042062. Epub 2012 Jul 26.
A number of studies assessed the association of cytotoxic T-lymphocyte associated antigen 4 (CTLA-4) gene polymorphisms with asthma in different populations. However, the results were contradictory. We performed a meta-analysis to examine the association between CTLA-4 polymorphisms and asthma susceptibility.
Pubmed, EMBASE, HuGE Navigator, and Wanfang Database were searched. Data were extracted independently by two reviewers. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations.
Seventeen studies involving 6378 cases and 8674 controls were included. Significant association between +49 A/G polymorphism and asthma was observed for AA vs. AG+GG (OR = 1.18, 95% CI 1.01-1.37, P = 0.04). There were no significant associations between -318 C/T, -1147 C/T, CT60 A/G, -1722 C/T, or rs926169 polymorphisms and asthma risk.
This meta-analysis suggested that the +49 A/G polymorphism in CTLA-4 was a risk factor for asthma.
多项研究评估了细胞毒性 T 淋巴细胞相关抗原 4（CTLA-4）基因多态性与不同人群哮喘之间的关联。然而，结果存在矛盾。我们进行了荟萃分析，以检验 CTLA-4 多态性与哮喘易感性之间的关联。
检索 Pubmed、EMBASE、HuGE Navigator 和万方数据库。由两名评审员独立提取数据。使用比值比（OR）及其 95%置信区间（CI）来评估关联的强度。
纳入了 17 项研究，涉及 6378 例病例和 8674 例对照。+49 A/G 多态性与 AA 相比 AG+GG 与哮喘显著相关（OR=1.18，95%CI 1.01-1.37，P=0.04）。-318 C/T、-1147 C/T、CT60 A/G、-1722 C/T 或 rs926169 多态性与哮喘风险之间无显著关联。
这项荟萃分析表明 CTLA-4 中的+49 A/G 多态性是哮喘的一个危险因素。
