Medical Center iMed24 and Jagiellonian University Medical College, Krakow, Poland.
Clin Exp Rheumatol. 2013 Nov-Dec;31(6):850-6. Epub 2013 Sep 30.
The objective of this study was to correlate dynamic contrast-enhanced MRI (DCE-MRI) perfusion parameters and conventional MRI scored with RAMRIS acquired from the wrists of patients with rheumatoid arthritis (RA).
Fifty-nine RA patients had conventional and DCE-MRI of the wrist using a low-field 0.2T ESAOTE extremity scanner. Synovitis, bone oedema and bone erosions were assessed using RAMRIS. DCE-MRI data were analysed using dedicated software Dynamika resulting in a set of perfusion parameters.
RAMRIS synovitis score and the number of enhancing pixels in DCE-MRI images have shown significant correlation. In this study, the parameters reflecting the dynamics of MRI signal enhancement (maximum enhancement, initial enhancement rate and the time of onset of enhancement) did not correlate with RAMRIS synovitis score, with bone oedema and with bone erosions scores.
One-way analysis of variance leads to conclusions consistent with the correlation analysis. There were cases of inflammation seen in axial images of a 3D T1-weighed gradient echo sequence not reflected in the perfusion data.
本研究旨在对类风湿关节炎（RA）患者腕关节的动态对比增强磁共振成像（DCE-MRI）灌注参数和采用 RAMRIS 获得的常规 MRI 评分进行相关性分析。
59 例 RA 患者采用低场 0.2T ESAOTE 四肢扫描仪进行腕关节常规和 DCE-MRI 检查。采用 RAMRIS 评估滑膜炎、骨水肿和骨侵蚀情况。DCE-MRI 数据使用专用软件 Dynamika 进行分析，得出一组灌注参数。
RAMRIS 滑膜炎评分与 DCE-MRI 图像中增强像素的数量呈显著相关性。在本研究中，反映 MRI 信号增强动力学的参数（最大增强、初始增强率和增强起始时间）与 RAMRIS 滑膜炎评分、骨水肿和骨侵蚀评分均无相关性。
方差分析的结论与相关性分析一致。在三维 T1 加权梯度回波序列的轴位图像中观察到的炎症病例，在灌注数据中并未反映出来。
