Spence J D
J Cardiovasc Pharmacol. 1985;7 Suppl 2:S121-5.
The treatment of hypertension is clearly beneficial. Blood pressure reduction with antihypertensive drugs reduces mortality and the incidence of complications such as stroke, renal failure, and congestive failure. However, analysis of long-term studies using different antihypertensive drugs indicates that the outcome of patients treated in those studies may be determined by effects of the antihypertensive drugs other than the lowering of blood pressure. Evidence is increasing that certain antihypertensive drugs have adverse effects on plasma lipid profiles that are of sufficient magnitude to offset the benefit of antihypertensive treatment in mild hypertensives. Furthermore, the effects of antihypertensive drugs on arterial flow disturbances, although they have received scant attention until now, may be important in the progression of atherosclerosis or even in the primary prevention of atherosclerosis. This article highlights differences in the effects of antihypertensive drugs on plasma lipids and on arterial flow disturbances as they may pertain to prevention of atherosclerosis.
高血压的治疗显然是有益的。使用抗高血压药物降低血压可降低死亡率以及中风、肾衰竭和充血性心力衰竭等并发症的发生率。然而，对使用不同抗高血压药物的长期研究分析表明，这些研究中接受治疗的患者的结局可能由抗高血压药物除降低血压之外的其他作用所决定。越来越多的证据表明，某些抗高血压药物对血浆脂质谱有不良影响，其程度足以抵消轻度高血压患者抗高血压治疗的益处。此外，抗高血压药物对动脉血流紊乱的影响，尽管到目前为止很少受到关注，但可能在动脉粥样硬化的进展甚至动脉粥样硬化的一级预防中起重要作用。本文重点介绍了抗高血压药物在血浆脂质和动脉血流紊乱方面的作用差异，因为它们可能与动脉粥样硬化的预防有关。
