抗高血压药物对血流速度的影响：对动脉粥样硬化形成的意义。
Effects of antihypertensive agents on blood velocity: implications for atherogenesis.
作者信息
Spence J D
出版信息
Can Med Assoc J. 1982 Oct 15;127(8):721-4.
Heart rate and blood velocity are major determinants of flow disturbances at arterial bifurcations. Since endothelial damage due to flow disturbances is thought to be significant in the pathogenesis of atherosclerosis, the effects of drugs on these parameters have to be considered in the selection of medications to prevent atherosclerosis. To determine the effects of antihypertensive drugs on heart rate and blood velocity 15 patients with hypertension were treated with placebo, hydrochlorothiazide, nadolol, propranolol and hydralazine in sequence. The doses given produced significant changes in heart rate and blood pressure, and Doppler ultrasonographic recording of aortic blood velocity showed that there were significant changes in peak blood velocity. Nadolol and propranolol produced significantly lower values of heart rate x blood velocity than placebo, hydralazine and hydrochlorothiazide.
心率和血流速度是动脉分叉处血流紊乱的主要决定因素。由于血流紊乱导致的内皮损伤被认为在动脉粥样硬化的发病机制中具有重要意义，因此在选择预防动脉粥样硬化的药物时，必须考虑药物对这些参数的影响。为了确定抗高血压药物对心率和血流速度的影响，对15名高血压患者依次给予安慰剂、氢氯噻嗪、纳多洛尔、普萘洛尔和肼屈嗪进行治疗。所给予的剂量使心率和血压产生了显著变化，主动脉血流速度的多普勒超声记录显示峰值血流速度也有显著变化。纳多洛尔和普萘洛尔产生的心率×血流速度值明显低于安慰剂、肼屈嗪和氢氯噻嗪。
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