Juárez-Reyes Krutzkaya, Angeles-López Guadalupe E, Rivero-Cruz Isabel, Bye Robert, Mata Rachel
Facultad de Química and.
Pharm Biol. 2014 Jan;52(1):14-20. doi: 10.3109/13880209.2013.805235. Epub 2013 Oct 4.
The roots and rhizomes of Ligusticum porteri Coulter & Rose (Apiaceae) are widely used in Mexican folk medicine for several purposes, including painful complaints.
The main goal of this work was to demonstrate the analgesic action in mice of some preparations and major compounds from L. porteri.
The extracts, aqueous (AE) and organic (OE), the essential oil (EO) and major compounds (10-316 mg/kg) from L. porteri were evaluated as potential antinociceptive agents using the acetic acid-induced writhing and hot plate tests in ICR mice.
All preparations tested exhibited significant antinociceptive effect in the two animal pain models selected. AE and EO were more effective in the writhing test while OE had a better effect in the hot-plate model. On the other hand, Z-ligustilide (1) provoked an increment in the latency period to the thermal stimuli in the hot-plate test at a dose of 31.6 mg/kg, and a decrease in the number of abdominal writhes at 10 mg/kg. Z-3-butylidenephthalide (2) induced a dose-dependent antinociceptive action in the hot-plate assay; this compound was also effective for controlling the pain provoked by chemical irritation at the doses of 10 and 31.6 mg/kg. Finally, diligustilide (3) inhibited the number of writhing responses at all doses tested but was inactive in the hot-plate model.
The present investigation provides in vivo evidence supporting the use of L. porteri to treat painful conditions in folk medicine.
波特川芎（伞形科）的根和根茎在墨西哥民间医学中被广泛用于多种用途，包括治疗疼痛。
本研究的主要目的是证明波特川芎的某些制剂和主要化合物对小鼠的镇痛作用。
使用ICR小鼠的醋酸诱导扭体试验和热板试验，评估波特川芎的水提取物（AE）、有机提取物（OE）、精油（EO）和主要化合物（10 - 316mg/kg）作为潜在的抗伤害感受剂。
在所选择的两种动物疼痛模型中，所有测试制剂均表现出显著的抗伤害感受作用。AE和EO在扭体试验中更有效，而OE在热板模型中效果更好。另一方面，Z-藁本内酯（1）在热板试验中，剂量为31.6mg/kg时可延长对热刺激的潜伏期，剂量为10mg/kg时可减少腹部扭体次数。Z-3-丁烯基苯酞（2）在热板试验中诱导出剂量依赖性的抗伤害感受作用；该化合物在10和31.6mg/kg剂量下对控制化学刺激引起的疼痛也有效。最后，二聚藁本内酯（3）在所有测试剂量下均抑制扭体反应次数，但在热板模型中无活性。
本研究提供了体内证据，支持在民间医学中使用波特川芎治疗疼痛病症。
