Ridtitid Wibool, Sae-Wong Chutha, Reanmongkol Wantana, Wongnawa Malinee
Department of Pharmacology, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.
J Ethnopharmacol. 2008 Jul 23;118(2):225-30. doi: 10.1016/j.jep.2008.04.002. Epub 2008 Apr 11.
Kaempferia galanga Linn. (Zingiberaceae) presents many chemical constituents of the volatile oil extracted from the rhizome. The rhizome of Kaempferia galanga is used by people in many regions for relieving toothache, abdominal pain, muscular swelling and rheumatism. In this study we investigated the antinociceptive activity in mice and rats using acetic acid-induced writhing, formalin, hot plate and tail-flick tests. The extract at test doses of 50, 100 and 200 mg/kg, p.o. clearly demonstrated antinociceptive activity in all tests. This activity was dose- and time-dependent. The extract administered at 200 mg/kg, p.o. had a stronger antinociceptive effect than aspirin (100 mg/kg, p.o.) but less than morphine (5 mg/kg, s.c.). Naloxone (2 mg/kg, i.p.) abolished the antinociceptive action of both morphine (5 mg/kg, s.c.) and the extract (200 mg/kg, p.o.) in a similar manner. In conclusion, the methanol extract of Kaempferia galanga markedly demonstrated the antinociceptive action in experimental animals. The antinociceptive mechanisms appear to be both peripherally and centrally mediated actions and the opioid receptors are probably involved. Therefore, our studies support the use in traditional medicine of Kaempferia galanga against pain caused by various disorders.
山柰（姜科）根茎中提取的挥发油含有多种化学成分。许多地区的人们使用山柰根茎来缓解牙痛、腹痛、肌肉肿胀和风湿。在本研究中，我们通过醋酸诱导扭体、福尔马林、热板和甩尾试验，研究了山柰在小鼠和大鼠中的抗伤害感受活性。受试剂量为50、100和200mg/kg口服给药的提取物在所有试验中均明显表现出抗伤害感受活性。这种活性具有剂量和时间依赖性。200mg/kg口服给药的提取物比阿司匹林（100mg/kg口服给药）具有更强的抗伤害感受作用，但比吗啡（5mg/kg皮下注射）弱。纳洛酮（2mg/kg腹腔注射）以类似方式消除了吗啡（5mg/kg皮下注射）和提取物（200mg/kg口服给药）的抗伤害感受作用。总之，山柰甲醇提取物在实验动物中明显表现出抗伤害感受作用。抗伤害感受机制似乎是外周和中枢介导的作用，可能涉及阿片受体。因此，我们的研究支持山柰在传统医学中用于治疗各种疾病引起的疼痛。
