Burnstock G
J Cardiovasc Pharmacol. 1985;7 Suppl 3:S137-46. doi: 10.1097/00005344-198500073-00016.
The recent discoveries of vascular neuroeffector control mechanisms, involving a wide variety of neurohumoral agents, pre- and postjunctional neuromodulation, and cotransmission, leave the field poised for growth in new directions. Some of these are outlined in this article, including: the development of methods for quantitation of the pattern and density of different types of perivascular nerves; exploration of the potent actions of purine nucleotides and nucleosides on vascular smooth muscle and/or endothelial cells, particularly in relation to the development of drugs of therapeutic potential; expansion of studies of the regulatory implications of cotransmitter release of ATP together with noradrenaline from some sympathetic perivascular nerves and of VIP together with acetylcholine from some parasympathetic nerves; autoradiographic localization of receptors for monoamines, peptides of and purines in blood vessels; wider studies of "axon reflex" control of the circulation and of the roles of substance P; investigation of development, aging, and regeneration of different perivascular nerve types, and the long-term "trophic" actions of some neurohumoral agents. Lastly, the time is ripe to study abnormalities in neurohumoral control of vessels in disease and after chronic exposure to drugs.
最近发现的血管神经效应器控制机制，涉及多种神经体液因子、突触前和突触后神经调制以及共传递，使该领域有望朝着新的方向发展。本文概述了其中一些方向，包括：开发定量不同类型血管周围神经的模式和密度的方法；探索嘌呤核苷酸和核苷对血管平滑肌和/或内皮细胞的强大作用，特别是与具有治疗潜力的药物开发相关的作用；扩展对某些交感神经血管周围神经中ATP与去甲肾上腺素共递质释放以及某些副交感神经中血管活性肠肽与乙酰胆碱共递质释放的调节意义的研究；血管中单胺、肽和嘌呤受体的放射自显影定位；对循环的“轴突反射”控制和P物质作用的更广泛研究；对不同类型血管周围神经的发育、衰老和再生以及某些神经体液因子的长期“营养”作用的研究。最后，研究疾病中和长期接触药物后血管神经体液控制异常的时机已经成熟。
