Departments of Pediatrics and Medicine, Division of Rheumatology, Penn State Hershey Children's Hospital .
Immunol Invest. 2013;42(8):673-90. doi: 10.3109/08820139.2013.837918.
Diagnostic test interference is due to the presence of material that falsely changes an analytic test result. The development of monoclonal antibodies is discussed with focus on their extensive use as both therapeutic and diagnostic agents. In this review the interference of monoclonal antibodies with laboratory test methods and the potential impact on clinical care is addressed. Recognition of the types of interference, endogenous and exogenous, and the varied mechanisms by which monoclonal antibodies may cause interference are discussed in this report. Review of the literature identifies cases which exemplify the issues facing laboratorians and clinicians and describe the impact on patients. Approaches to reducing and eliminating sources of interference are also addressed. Education of ordering clinicians concerning the possibility of interference in at-risk patients is key in limiting the impact on care. Laboratorians and medical practitioners should be cognizant of the risk of interference to avoid incorrect management of patients.
诊断性检测干扰是由于存在可错误改变分析性检测结果的物质所致。本文讨论了单克隆抗体的发展，重点是它们作为治疗剂和诊断剂的广泛应用。在本综述中，探讨了单克隆抗体对实验室检测方法的干扰以及对临床护理的潜在影响。本报告讨论了识别内源性和外源性干扰类型以及单克隆抗体可能引起干扰的不同机制。文献复习确定了一些案例，这些案例说明了检验人员和临床医生所面临的问题，并描述了对患者的影响。还探讨了减少和消除干扰源的方法。教育开单医生注意高危患者存在干扰的可能性是限制对患者护理影响的关键。检验人员和医疗从业者应该意识到干扰的风险，以避免对患者的不正确管理。
