构建大脑。
Build-a-brain.
机构信息
Center for Stem Cell Biology, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10065, USA; Developmental Biology Program, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10065, USA.
出版信息
Cell Stem Cell. 2013 Oct 3;13(4):377-8. doi: 10.1016/j.stem.2013.09.010.
A major barrier in understanding nervous system development is modeling the cellular interactions that form the human brain. Recently, in the journal Nature, Lancaster et al. (2013) established a protocol for culturing pluripotent stem cell (PSC)-derived "cerebral organoids" that mimics the developing human brain's cellular organization, segregates into distinct brain regions, and models microcephaly.
理解神经系统发育的主要障碍是模拟形成人类大脑的细胞相互作用。最近，在《自然》杂志上，兰开斯特等人（2013）建立了一种培养多能干细胞（PSC）衍生的“类脑器官”的方案，该方案模拟了发育中人类大脑的细胞组织，可分离成不同的脑区，并可模拟小头畸形。
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