利用大脑类器官模拟人类大脑发育。
Modeling human brain development with cerebral organoids.
出版信息
Stem Cell Res Ther. 2013;4(6):154. doi: 10.1186/scrt384.
Abstract
The recent discovery of a new three-dimensional culture system for the derivation of cerebral organoids from human induced pluripotent stem cells provides developmental neurobiologists with the first example of a three-dimensional framework for the study of human brain development. This innovative approach permits the in vitro assembly of a human embryonic brain rudiment that recapitulates the developing human cerebrum. Organoids contain progenitor populations that develop to yield mature cortical neuron subtypes, potentially allowing investigators to study complex brain diseases that lack appropriate animal models.
摘要
最近发现了一种新的三维培养系统，可从人类诱导多能干细胞中衍生出大脑类器官，为发育神经生物学家提供了研究人类大脑发育的第一个三维框架范例。这种创新方法允许在体外组装一个重现人类大脑发育的人类胚胎脑原基。类器官包含祖细胞群体，这些细胞可发育为成熟的皮质神经元亚型，这可能使研究人员能够研究缺乏适当动物模型的复杂脑部疾病。
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