Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, 35 Medical Center Way, San Francisco, CA 94143, USA; University of California, San Francisco, San Francisco, CA 94143, USA.
Cell. 2013 Sep 26;155(1):19-20. doi: 10.1016/j.cell.2013.09.010.
A three-dimensional culture of cortical tissues derived from pluripotent stem cells offers an opportunity to model human brain development and disorders. In a recent issue of Nature, Lancaster et al. describe a new method for generating cerebral organoids in a dish and use it to model microcephaly.
多能干细胞衍生的皮质组织的三维培养为模拟人类大脑发育和疾病提供了机会。在最近的一期《自然》杂志上,Lancaster 等人描述了一种在培养皿中生成大脑类器官的新方法,并利用该方法对小头畸形进行了建模。