Imamura Takashi, Watanabe Masahiro, Kaneko Mariko, Shibukawa Yasuko, Fukuda Yutaka, Nagasawa Katsutoshi
Department of Pediatrics, Takeda General Hospital, 3-27, Yamagamachi, Aidu Wakamatsu City, Fukushima 965-8585, Japan.
Department of Pediatrics, Takeda General Hospital, 3-27, Yamagamachi, Aidu Wakamatsu City, Fukushima 965-8585, Japan.
Pediatr Neonatol. 2016 Feb;57(1):69-71. doi: 10.1016/j.pedneo.2013.06.008. Epub 2013 Oct 2.
Because the role of eosinophils in neonates is not well understood, the clinical significance of eosinophilia in neonates is unclear. We encountered a rare case of cow's milk allergy in a premature male infant with severe eosinophilia in the neonatal period. The peripheral blood eosinophil count in this infant was 7,404/μL at birth, and he produced stools with fresh blood immediately after birth and prior to the first feedings with regular cow's milk. Although the patient's eosinophil count normalized without specific treatment within 6 weeks after birth, it is possible that the causes of the eosinophilia in this infant prior to the first feedings with regular cow's milk were different from those after the first feedings. Cow's milk allergy was diagnosed on the basis of the patient's positivity for this allergy in the challenge test and subsequent allergen-specific lymphocyte stimulation test performed at 6 months of age.
由于嗜酸性粒细胞在新生儿中的作用尚未得到充分了解，新生儿嗜酸性粒细胞增多的临床意义尚不清楚。我们遇到了一例罕见的早产儿牛奶过敏病例，该男婴在新生儿期出现严重嗜酸性粒细胞增多。该婴儿出生时外周血嗜酸性粒细胞计数为7404/μL，出生后首次喂食常规牛奶之前即排出带鲜血的粪便。尽管该患者的嗜酸性粒细胞计数在出生后6周内未经特殊治疗便恢复正常，但首次喂食常规牛奶之前该婴儿嗜酸性粒细胞增多的原因可能与首次喂食之后不同。根据该患者在6个月大时进行的激发试验及随后的过敏原特异性淋巴细胞刺激试验呈阳性，诊断为牛奶过敏。
