破裂性和未破裂性腹主动脉瘤患者的血栓体积相似。
Thrombus volume is similar in patients with ruptured and intact abdominal aortic aneurysms.
机构信息
The Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, School of Medicine and Dentistry, James Cook University, Townsville, Australia; Department of Vascular and Endovascular Surgery, The Townsville Hospital, Townsville, Australia; University of Queensland School of Medicine and Centre for Clinical Research, Brisbane, Australia.
University of Queensland School of Medicine and Centre for Clinical Research, Brisbane, Australia.
出版信息
J Vasc Surg. 2014 Feb;59(2):315-20. doi: 10.1016/j.jvs.2013.08.036. Epub 2013 Oct 3.
OBJECTIVE
Most abdominal aortic aneurysms (AAAs) contain intraluminal thrombus (ILT), which has been demonstrated to contain proteolytic enzymes and proinflammatory cytokines implicated in AAA progression and rupture. In animal models, anticoagulants have been shown to limit AAA progression. Whether ILT plays a role in AAA rupture is unknown. The aim of this study was to compare the volume of ILT in patients with ruptured and intact AAAs.
METHODS
We matched by maximum axial diameter alone, on a 1:2 basis, 28 patients with ruptured AAAs and 56 patients with intact AAAs. Total infrarenal aortic volume and ILT volume were measured from computed tomography angiograms using a previously validated and reproducible semiautomated workstation protocol. Clinical risk factors were also recorded. The Mann-Whitney U test was used to compare ILT volumes between patients with ruptured and intact AAAs.
RESULTS
Median (interquartile range [IQR]) maximum AAA diameter (84.0 [77.5-93.9] mm vs 82.6 [77.1-93.3] mm; P = .769) and median (IQR) total AAA volume (372.8 [277.4-486.1] cm(3) vs 358.4 [289.1-563.4] cm(3); P = .977) were similar in patients with ruptured and intact AAAs. Median (IQR) AAA ILT volume was similar in patients with ruptured (152.7 [84.8-252.4] cm(3)) and intact (180.1 [89.9-254.8] cm(3); P = .414) AAAs.
CONCLUSIONS
This study suggests that ILT volume is not different in ruptured and intact AAAs.
目的
大多数腹主动脉瘤（AAA）都包含腔内血栓（ILT），其中已证实含有与 AAA 进展和破裂相关的蛋白水解酶和促炎细胞因子。在动物模型中，抗凝剂已被证明可以限制 AAA 的进展。ILT 是否在 AAA 破裂中起作用尚不清楚。本研究旨在比较破裂和未破裂 AAA 患者的 ILT 体积。
方法
我们单独根据最大轴向直径，以 1:2 的比例匹配了 28 例破裂性 AAA 患者和 56 例未破裂性 AAA 患者。使用经过先前验证和可重复的半自动工作站方案，从 CT 血管造影中测量腹主动脉下段总容积和 ILT 容积。还记录了临床危险因素。采用 Mann-Whitney U 检验比较破裂性和未破裂性 AAA 患者的 ILT 体积。
结果
中位数（四分位距 [IQR]）最大 AAA 直径（84.0 [77.5-93.9]mm 与 82.6 [77.1-93.3]mm；P =.769）和中位数（IQR）总 AAA 体积（372.8 [277.4-486.1]cm(3)与 358.4 [289.1-563.4]cm(3)；P =.977）在破裂性和未破裂性 AAA 患者中相似。破裂性（152.7 [84.8-252.4]cm(3)）和未破裂性（180.1 [89.9-254.8]cm(3)；P =.414）AAA 患者的 AAA ILT 体积中位数（IQR）相似。
结论
本研究表明，破裂和未破裂 AAA 中的 ILT 体积没有差异。
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