Division of Cancer Epidemiology and Prevention, Institute of Social and Preventive Medicine, University of Zurich, Zurich, Switzerland; Unit of Demography and Health Statistics, Institute of Social and Preventive Medicine, University of Zurich, Zurich, Switzerland.
Nutr Metab Cardiovasc Dis. 2013 Oct;23(10):960-6. doi: 10.1016/j.numecd.2013.05.005. Epub 2013 Oct 3.
In various populations, vitamin D deficiency is associated with chronic diseases and mortality. We examined the association between concentration of circulating 25-hydroxyvitamin D [25(OH)D], a marker of vitamin D status, and all-cause as well as cause-specific mortality.
The study included 3404 participants of the general adult Swiss population, who were recruited between November 1988 and June 1989 and followed-up until the end of 2008. Circulating 25(OH)D was measured by protein-bound assay. Cox proportional hazards regression was used to examine the association between 25(OH)D concentration and all-cause and cause-specific mortality adjusting for sex, age, season, diet, nationality, blood pressure, and smoking status. Per 10 ng/mL increase in 25(OH)D concentration, all-cause mortality decreased by 20% (HR = 0.83; 95% CI 0.74-0.92). 25(OH)D concentration was inversely associated with cardiovascular mortality in women (HR = 0.68, 95% CI 0.46-1.00 per 10 ng/mL increase), but not in men (HR = 0.97; 95% CI 0.77-1.23). In contrast, 25(OH)D concentration was inversely associated with cancer mortality in men (HR = 0.72, 95% CI 0.57-0.91 per 10 ng/mL increase), but not in women (HR = 1.14, 95% CI 0.93-1.39). Multivariate adjustment only slightly modified the 25(OH)D-mortality association.
25(OH)D was similarly inversely related to all-cause mortality in men and women. However, we observed opposite effects in women and men with respect to cardiovascular and cancer mortality.
在不同人群中，维生素 D 缺乏与慢性病和死亡率有关。我们研究了循环 25-羟维生素 D [25(OH)D]浓度与全因死亡率和死因特异性死亡率之间的关系，25(OH)D 是维生素 D 状态的标志物。
这项研究纳入了瑞士普通成年人群中的 3404 名参与者，他们于 1988 年 11 月至 1989 年 6 月间招募，并随访至 2008 年底。循环 25(OH)D 通过蛋白结合法测定。Cox 比例风险回归用于检验 25(OH)D 浓度与全因死亡率和死因特异性死亡率之间的关系，调整性别、年龄、季节、饮食、国籍、血压和吸烟状况。25(OH)D 浓度每增加 10ng/ml，全因死亡率降低 20%（HR=0.83；95%CI 0.74-0.92）。25(OH)D 浓度与女性心血管死亡率呈负相关（每增加 10ng/ml，HR=0.68，95%CI 0.46-1.00），但与男性无关（HR=0.97；95%CI 0.77-1.23）。相反，25(OH)D 浓度与男性癌症死亡率呈负相关（每增加 10ng/ml，HR=0.72，95%CI 0.57-0.91），但与女性无关（HR=1.14，95%CI 0.93-1.39）。多变量调整仅略微改变了 25(OH)D-死亡率之间的关系。
25(OH)D 与男性和女性的全因死亡率呈负相关。然而，我们观察到女性和男性在心血管疾病和癌症死亡率方面的影响相反。
